PSCA (gene)
From Wikipedia, the free encyclopedia
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Prostate stem cell antigen
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| Identifiers | |||||||||||
| Symbol(s) | PSCA; PRO232 | ||||||||||
| External IDs | OMIM: 602470 MGI: 1919623 HomoloGene: 4150 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 8000 | 72373 | |||||||||
| Ensembl | ENSG00000167653 | ENSMUSG00000022598 | |||||||||
| Uniprot | O43653 | Q9D7U0 | |||||||||
| Refseq | NM_005672 (mRNA) NP_005663 (protein) |
NM_028216 (mRNA) NP_082492 (protein) |
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| Location | Chr 8: 143.76 - 143.76 Mb | Chr 15: 74.54 - 74.54 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
Prostate stem cell antigen, also known as PSCA, is a human gene.[1]
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene has a nonsynonymous nucleotide polymorphism at its start codon.[1]
[edit] References
[edit] Further reading
- Reiter RE, Gu Z, Watabe T, et al. (1998). "Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer.". Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1735-40. PMID 9465086.
- Gu Z, Thomas G, Yamashiro J, et al. (2000). "Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer.". Oncogene 19 (10): 1288-96. doi:. PMID 10713670.
- Bahrenberg G, Brauers A, Joost HG, Jakse G (2000). "Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors.". Biochem. Biophys. Res. Commun. 275 (3): 783-8. doi:. PMID 10973799.
- Amara N, Palapattu GS, Schrage M, et al. (2001). "Prostate stem cell antigen is overexpressed in human transitional cell carcinoma.". Cancer Res. 61 (12): 4660-5. PMID 11406532.
- Watabe T, Lin M, Ide H, et al. (2002). "Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 401-6. doi:. PMID 11752398.
- Ross S, Spencer SD, Holcomb I, et al. (2002). "Prostate stem cell antigen as therapy target: tissue expression and in vivo efficacy of an immunoconjugate.". Cancer Res. 62 (9): 2546-53. PMID 11980648.
- Jain A, Lam A, Vivanco I, et al. (2003). "Identification of an androgen-dependent enhancer within the prostate stem cell antigen gene.". Mol. Endocrinol. 16 (10): 2323-37. PMID 12351697.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Tran CP, Lin C, Yamashiro J, Reiter RE (2003). "Prostate stem cell antigen is a marker of late intermediate prostate epithelial cells.". Mol. Cancer Res. 1 (2): 113-21. PMID 12496358.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:. PMID 14702039.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
- Fraga MF, Ballestar E, Villar-Garea A, et al. (2005). "Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.". Nat. Genet. 37 (4): 391-400. doi:. PMID 15765097.
- Lam JS, Yamashiro J, Shintaku IP, et al. (2005). "Prostate stem cell antigen is overexpressed in prostate cancer metastases.". Clin. Cancer Res. 11 (7): 2591-6. doi:. PMID 15814638.
- Zhigang Z, Wenlu S (2006). "Complete androgen ablation suppresses prostate stem cell antigen (PSCA) mRNA expression in human prostate carcinoma.". Prostate 65 (4): 299-305. doi:. PMID 16015594.
- Wente MN, Jain A, Kono E, et al. (2006). "Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer.". Pancreas 31 (2): 119-25. PMID 16024997.
- Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942-54. doi:. PMID 16341674.
- Grubbs EG, Abdel-Wahab Z, Tyler DS, Pruitt SK (2007). "Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer.". Ann. Surg. Oncol. 13 (12): 1645-54. doi:. PMID 16957968.
- Morgenroth A, Cartellieri M, Schmitz M, et al. (2007). "Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells.". Prostate 67 (10): 1121-31. doi:. PMID 17492652.
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