PLCG1

From Wikipedia, the free encyclopedia

Phospholipase C, gamma 1
PDB rendering based on 1hsq.
Available structures: 1hsq, 1y0m, 1ywo, 1ywp, 2fci, 2hsp, 2pld, 2ple
Identifiers
Symbol(s)	PLCG1; PLC-II; PLC1; PLC148; PLCgamma1
External IDs	OMIM: 172420 MGI: 97615 HomoloGene: 1997
Gene ontology Molecular Function: • phosphoinositide phospholipase C activity • signal transducer activity • receptor signaling protein activity • calcium ion binding • protein binding • hydrolase activity Cellular Component: • cellular_component Biological Process: • in utero embryonic development • intracellular signaling cascade • lipid catabolic process
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	5335	18803
Ensembl	ENSG00000124181	ENSMUSG00000016933
Uniprot	P19174	Q2M4I9
Refseq	NM_002660 (mRNA) NP_002651 (protein)	NM_021280 (mRNA) NP_067255 (protein)
Location	Chr 20: 39.2 - 39.24 Mb	Chr 2: 160.42 - 160.47 Mb
Pubmed search	[1]	[2]

Phospholipase C, gamma 1, also known as PLCG1, is a human gene.

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] See also

• Phospholipase C

[edit] References