PLCB4

From Wikipedia, the free encyclopedia

Phospholipase C, beta 4

Identifiers

PLCB4; PI-PLC; FLJ16169

External IDs

OMIM: 600810 MGI: 107464 HomoloGene: 8471

Gene ontology
Molecular Function:	• phosphoinositide phospholipase C activity • signal transducer activity • calcium ion binding • protein binding • hydrolase activity
Biological Process:	• lipid metabolic process • intracellular signaling cascade • lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_000933 (mRNA)
NP_000924 (protein)

NM_013829 (mRNA)
NP_038857 (protein)

Location

Chr 20: 9.02 - 9.41 Mb

Chr 2: 135.5 - 135.7 Mb

Pubmed search

[1]

[2]

Phospholipase C, beta 4, also known as PLCB4, is a human gene.^[1]

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PLCB4 phospholipase C, beta 4.

[edit] Further reading

Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117–24. PMID 1979339.
Zauli G, Previati M, Caramelli E, et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.". Eur. J. Immunol. 25 (9): 2695–700. PMID 7589147.
Alvarez RA, Ghalayini AJ, Xu P, et al. (1996). "cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4).". Genomics 29 (1): 53–61. doi:10.1006/geno.1995.1214. PMID 8530101.
Lyu MS, Park DJ, Rhee SG, Kozak CA (1996). "Genetic mapping of the human and mouse phospholipase C genes.". Mamm. Genome 7 (7): 501–4. PMID 8672127.
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385–8. PMID 9278385.
Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3-4): 184–92. PMID 9730685.
Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.". J. Neurochem. 73 (4): 1363–74. PMID 10501179.
Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538–42. PMID 10843712.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.". Virology 303 (1): 174–80. PMID 12482669.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hahn CG, Wang HY, Cho DS, et al. (2006). "Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia.". Nat. Med. 12 (7): 824–8. doi:10.1038/nm1418. PMID 16767099.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.