PKIA
From Wikipedia, the free encyclopedia
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Protein kinase (cAMP-dependent, catalytic) inhibitor alpha
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| Identifiers | |||||||||||
| Symbol(s) | PKIA; PRKACN1 | ||||||||||
| External IDs | OMIM: 606059 MGI: 104747 HomoloGene: 7473 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 5569 | 18767 | |||||||||
| Ensembl | ENSG00000171033 | ENSMUSG00000027499 | |||||||||
| Uniprot | P61925 | Q3UTL0 | |||||||||
| Refseq | NM_006823 (mRNA) NP_006814 (protein) |
NM_008862 (mRNA) NP_032888 (protein) |
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| Location | Chr 8: 79.67 - 79.68 Mb | Chr 3: 7.35 - 7.43 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
Protein kinase (cAMP-dependent, catalytic) inhibitor alpha, also known as PKIA, is a human gene.[1]
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported.[1]
[edit] References
[edit] Further reading
- Olsen SR, Uhler MD (1991). "Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase.". J. Biol. Chem. 266 (17): 11158–62. PMID 1710219.
- Olsen SR, Uhler MD (1992). "Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor.". Mol. Endocrinol. 5 (9): 1246–56. PMID 1770951.
- Knighton DR, Zheng JH, Ten Eyck LF, et al. (1991). "Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.". Science 253 (5018): 414–20. PMID 1862343.
- Van Patten SM, Heisermann GJ, Cheng HC, Walsh DA (1987). "Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase.". J. Biol. Chem. 262 (7): 3398–403. PMID 2434500.
- Scott JD, Fischer EH, Demaille JG, Krebs EG (1985). "Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase.". Proc. Natl. Acad. Sci. U.S.A. 82 (13): 4379–83. PMID 2989819.
- Scott JD, Glaccum MB, Fischer EH, Krebs EG (1986). "Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase.". Proc. Natl. Acad. Sci. U.S.A. 83 (6): 1613–6. PMID 3456605.
- Wen W, Taylor SS, Meinkoth JL (1995). "The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated.". J. Biol. Chem. 270 (5): 2041–6. PMID 7836431.
- Baude EJ, Dignam SS, Olsen SR, et al. (1994). "Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor.". J. Biol. Chem. 269 (3): 2316–23. PMID 7905001.
- Baude EJ, Dignam SS, Reimann EM, Uhler MD (1994). "Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors.". J. Biol. Chem. 269 (27): 18128–33. PMID 8027074.
- Fritz CC, Green MR (1997). "HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs.". Curr. Biol. 6 (7): 848–54. PMID 8805303.
- Zimmermann B, Chiorini JA, Ma Y, et al. (1999). "PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I.". J. Biol. Chem. 274 (9): 5370–8. PMID 10026146.
- Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors.". Brain Res. Mol. Brain Res. 99 (2): 145–9. PMID 11978406.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Gassel M, Breitenlechner CB, Rüger P, et al. (2003). "Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT).". J. Mol. Biol. 329 (5): 1021–34. PMID 12798691.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
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