PCNT

From Wikipedia, the free encyclopedia

Pericentrin (kendrin)

Identifiers

PCNT; KEN; PCN; PCNT2; PCNTB; PCTN2

External IDs

OMIM: 605925 MGI: 102722 HomoloGene: 86942

Gene ontology
Molecular Function:	• calmodulin binding
Cellular Component:	• centriole
Biological Process:	• spindle organization and biogenesis • cilium biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006031 (mRNA)
NP_006022 (protein)

XM_622782 (mRNA)
XP_622782 (protein)

Location

Chr 21: 46.57 - 46.69 Mb

Chr 10: 75.79 - 75.89 Mb

Pubmed search

[1]

[2]

Pericentrin (kendrin), also known as PCNT, is a human gene.^[1]

The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression.^[1]

[edit] References

^ ^a ^b Entrez Gene: PCNT pericentrin (kendrin).

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Chen H, Gos A, Morris MA, Antonarakis SE (1996). "Localization of a human homolog of the mouse pericentrin gene (PCNT) to chromosome 21qter.". Genomics 35 (3): 620-4. doi:10.1006/geno.1996.0411. PMID 8812505.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307-13. PMID 9455477.
Diviani D, Langeberg LK, Doxsey SJ, Scott JD (2000). "Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain.". Curr. Biol. 10 (7): 417-20. PMID 10753751.
Flory MR, Moser MJ, Monnat RJ, Davis TN (2000). "Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin.". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5919-23. PMID 10823944.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311-9. doi:10.1038/35012518. PMID 10830953.
Li Q, Hansen D, Killilea A, et al. (2001). "Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1.". J. Cell. Sci. 114 (Pt 4): 797-809. PMID 11171385.
Takahashi M, Yamagiwa A, Nishimura T, et al. (2003). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.". Mol. Biol. Cell 13 (9): 3235-45. doi:10.1091/mbc.E02-02-0112. PMID 12221128.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Flory MR, Davis TN (2004). "The centrosomal proteins pericentrin and kendrin are encoded by alternatively spliced products of one gene.". Genomics 82 (3): 401-5. PMID 12906865.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Chang F, Re F, Sebastian S, et al. (2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.". Mol. Biol. Cell 15 (4): 1793-801. doi:10.1091/mbc.E03-09-0691. PMID 14767062.
Miyoshi K, Asanuma M, Miyazaki I, et al. (2004). "DISC1 localizes to the centrosome by binding to kendrin.". Biochem. Biophys. Res. Commun. 317 (4): 1195-9. doi:10.1016/j.bbrc.2004.03.163. PMID 15094396.
Jurczyk A, Gromley A, Redick S, et al. (2004). "Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly.". J. Cell Biol. 166 (5): 637-43. doi:10.1083/jcb.200405023. PMID 15337773.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Golubkov VS, Chekanov AV, Doxsey SJ, Strongin AY (2006). "Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis.". J. Biol. Chem. 280 (51): 42237-41. doi:10.1074/jbc.M510139200. PMID 16251193.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391-6. doi:10.1073/pnas.0507066103. PMID 16565220.