PCM1

From Wikipedia, the free encyclopedia

Pericentriolar material 1

Identifiers

PCM1; PTC4

External IDs

OMIM: 600299 MGI: 1277958 HomoloGene: 4518

Gene ontology
Cellular Component:	• pericentriolar material • cytoplasm • cytoskeleton

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006197 (mRNA)
NP_006188 (protein)

XM_622941 (mRNA)
XP_622941 (protein)

Location

Chr 8: 17.82 - 17.93 Mb

Chr 8: 42.74 - 42.83 Mb

Pubmed search

[1]

[2]

Pericentriolar material 1, also known as PCM1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PCM1 pericentriolar material 1.

[edit] Further reading

Ohata H, Fujiwara Y, Koyama K, Nakamura Y (1995). "Mapping of the human autoantigen pericentriolar material 1 (PCM1) gene to chromosome 8p21.3-p22.". Genomics 24 (2): 404-6. doi:10.1006/geno.1994.1640. PMID 7698772.
Balczon R, Bao L, Zimmer WE (1994). "PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution.". J. Cell Biol. 124 (5): 783-93. PMID 8120099.
Engelender S, Sharp AH, Colomer V, et al. (1998). "Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.". Hum. Mol. Genet. 6 (13): 2205-12. PMID 9361024.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
Corvi R, Berger N, Balczon R, Romeo G (2000). "RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma.". Oncogene 19 (37): 4236-42. doi:10.1038/sj.onc.1203772. PMID 10980597.
Li Q, Hansen D, Killilea A, et al. (2001). "Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1.". J. Cell. Sci. 114 (Pt 4): 797-809. PMID 11171385.
Kumar S, Connor JR, Dodds RA, et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.". Osteoarthr. Cartil. 9 (7): 641-53. doi:10.1053/joca.2001.0421. PMID 11597177.
Dammermann A, Merdes A (2002). "Assembly of centrosomal proteins and microtubule organization depends on PCM-1.". J. Cell Biol. 159 (2): 255-66. doi:10.1083/jcb.200204023. PMID 12403812.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ansley SJ, Badano JL, Blacque OE, et al. (2003). "Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.". Nature 425 (6958): 628-33. doi:10.1038/nature02030. PMID 14520415.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Kim JC, Badano JL, Sibold S, et al. (2004). "The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.". Nat. Genet. 36 (5): 462-70. doi:10.1038/ng1352. PMID 15107855.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763-72. doi:10.1021/ac035352d. PMID 15144186.
Armes JE, Hammet F, de Silva M, et al. (2004). "Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers.". Oncogene 23 (33): 5697-702. doi:10.1038/sj.onc.1207740. PMID 15184884.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hames RS, Crookes RE, Straatman KR, et al. (2005). "Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.". Mol. Biol. Cell 16 (4): 1711-24. doi:10.1091/mbc.E04-08-0688. PMID 15659651.
Reiter A, Walz C, Watmore A, et al. (2005). "The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2.". Cancer Res. 65 (7): 2662-7. doi:10.1158/0008-5472.CAN-04-4263. PMID 15805263.
Murati A, Gelsi-Boyer V, Adélaïde J, et al. (2005). "PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation.". Leukemia 19 (9): 1692-6. doi:10.1038/sj.leu.2403879. PMID 16034466.