Paramethadione


Paramethadione
Systematic (IUPAC) name
5-ethyl-3,5-dimethyl-oxazolidine-2,4-dione
Identifiers
CAS number	115-67-3
ATC code	N03AC01
PubChem	8280
DrugBank	APRD00236
Chemical data
Formula	C₇H₁₁N O₃
Mol. mass	157.167 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	Not significant
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	D(US)
Legal status
Routes	?

Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.^[1]

[edit] References

DDB 33106
Hoffman, D; Chun A (1975). "Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose". J Pharm Sci 64 (10): 1702–1703. doi:10.1002/jps.2600641027. PMID 1185541.

v • d • e Anticonvulsants (N03)

Barbiturates	Barbexaclone, Metharbital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone

Hydantoins	Ethotoin, Fosphenytoin, Mephenytoin, Phenytoin

Oxazolidinediones	Ethadione, Paramethadione, Trimethadione

Succinimides	Ethosuximide, Mesuximide, Phensuximide

Benzodiazepines	Clobazam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Midazolam, Nimetazepam, Nitrazepam, Temazepam

Carboxamides	Carbamazepine, Oxcarbazepine, Rufinamide

Fatty acid derivatives	Valpromide, Valnoctamide

Carboxylic acids	Valproic acid (Sodium valproate & Valproate semisodium), Tiagabine

Others	GABA analogs: Gabapentin, Pregabalin, Progabide, Vigabatrin -- Monosaccharides: Topiramate -- Aromatic allylic alcohols: Stiripentol -- Ureas: Phenacemide, Pheneturide -- Phenyltriazines: Lamotrigine Carbamates: Emylcamate, Felbamate, Meprobamate -- Pyrrolidines: Brivaracetam, Levetiracetam, Nefiracetam, Seletracetam Sulfa drugs: Acetazolamide, Ethoxzolamide, Sultiame, Zonisamide -- Propionates: Beclamide -- Aldehydes: Paraldehyde -- Bromides: Potassium bromide, Sodium bromide

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