NUP214

From Wikipedia, the free encyclopedia

Nucleoporin 214kDa

PDB rendering based on 2oit.

Available structures: 2oit

Identifiers

Symbol(s)

NUP214; CAIN; CAN; D9S46E; MGC104525; N214

External IDs

OMIM: 114350 MGI: 1095411 HomoloGene: 38008

Gene ontology
Molecular Function:	• molecular_function • transporter activity • protein binding • porin activity
Cellular Component:	• nucleus • nuclear pore • integral to membrane • outer membrane
Biological Process:	• protein export from nucleus • transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_005085 (mRNA)
NP_005076 (protein)

XM_358340 (mRNA)
XP_358340 (protein)

Location

Chr 9: 132.99 - 133.1 Mb

Chr 2: 31.8 - 31.87 Mb

Pubmed search

[1]

[2]

Nucleoporin 214kDa, also known as NUP214, is a human gene.^[1]

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome.^[1]

[edit] References

^ ^a ^b Entrez Gene: NUP214 nucleoporin 214kDa.

[edit] Further reading

Stoffler D, Fahrenkrog B, Aebi U (1999). "The nuclear pore complex: from molecular architecture to functional dynamics.". Curr. Opin. Cell Biol. 11 (3): 391–401. doi:10.1016/S0955-0674(99)80055-6. PMID 10395558.
von Lindern M, Fornerod M, van Baal S, et al. (1992). "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.". Mol. Cell. Biol. 12 (4): 1687–97. PMID 1549122.
von Lindern M, Poustka A, Lerach H, Grosveld G (1990). "The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34.". Mol. Cell. Biol. 10 (8): 4016–26. PMID 2370860.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.". DNA Res. 1 (1): 27–35. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47–56. PMID 7584028.
Pilz A, Woodward K, Povey S, Abbott C (1995). "Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse.". Genomics 25 (1): 139–49. PMID 7774911.
Kraemer D, Wozniak RW, Blobel G, Radu A (1994). "The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm.". Proc. Natl. Acad. Sci. U.S.A. 91 (4): 1519–23. PMID 8108440.
Stutz F, Izaurralde E, Mattaj IW, Rosbash M (1997). "A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus.". Mol. Cell. Biol. 16 (12): 7144–50. PMID 8943370.
Fornerod M, van Deursen J, van Baal S, et al. (1997). "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88.". EMBO J. 16 (4): 807–16. doi:10.1093/emboj/16.4.807. PMID 9049309.
Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin beta3.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451–6. PMID 9114010.
Bonifaci N, Moroianu J, Radu A, Blobel G (1997). "Karyopherin beta2 mediates nuclear import of a mRNA binding protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5055–60. PMID 9144189.
Bastos R, Ribas de Pouplana L, Enarson M, et al. (1997). "Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex.". J. Cell Biol. 137 (5): 989–1000. PMID 9166401.
Boer J, Bonten-Surtel J, Grosveld G (1998). "Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis.". Mol. Cell. Biol. 18 (3): 1236–47. PMID 9488438.
Bogerd HP, Echarri A, Ross TM, Cullen BR (1998). "Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1.". J. Virol. 72 (11): 8627–35. PMID 9765402.
Zolotukhin AS, Felber BK (1999). "Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev.". J. Virol. 73 (1): 120–7. PMID 9847314.
Schmitt C, von Kobbe C, Bachi A, et al. (1999). "Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p.". EMBO J. 18 (15): 4332–47. doi:10.1093/emboj/18.15.4332. PMID 10428971.
Bachi A, Braun IC, Rodrigues JP, et al. (2000). "The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.". RNA 6 (1): 136–58. PMID 10668806.
Herold A, Suyama M, Rodrigues JP, et al. (2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.". Mol. Cell. Biol. 20 (23): 8996–9008. PMID 11073998.
Hofmann W, Reichart B, Ewald A, et al. (2001). "Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin.". J. Cell Biol. 152 (5): 895–910. PMID 11238447.