NOV (gene)

From Wikipedia, the free encyclopedia

Nephroblastoma overexpressed gene

Identifiers

NOV; CCN3; IGFBP9; NOVH

External IDs

OMIM: 164958 MGI: 109185 HomoloGene: 1884

Gene ontology
Molecular Function:	• insulin-like growth factor binding • growth factor activity
Cellular Component:	• extracellular region
Biological Process:	• regulation of cell growth

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002514 (mRNA)
NP_002505 (protein)

NM_010930 (mRNA)
NP_035060 (protein)

Location

Chr 8: 120.5 - 120.51 Mb

Chr 15: 54.58 - 54.58 Mb

Pubmed search

[1]

[2]

Nephroblastoma overexpressed gene, also known as NOV, is a human gene.^[1]

[edit] References

^ Entrez Gene: NOV nephroblastoma overexpressed gene.

[edit] Further reading

Perbal B (2007). "The CCN3 protein and cancer.". Adv. Exp. Med. Biol. 587: 23–40. PMID 17163153.
Martinerie C, Viegas-Pequignot E, Guenard I, et al. (1993). "Physical mapping of human loci homologous to the chicken nov proto-oncogene.". Oncogene 7 (12): 2529–34. PMID 1334251.
Martinerie C, Huff V, Joubert I, et al. (1994). "Structural analysis of the human nov proto-oncogene and expression in Wilms tumor.". Oncogene 9 (9): 2729–32. PMID 7520150.
Martinerie C, Chevalier G, Rauscher FJ, Perbal B (1996). "Regulation of nov by WT1: a potential role for nov in nephrogenesis.". Oncogene 12 (7): 1479–92. PMID 8622864.
Perbal B, Martinerie C, Sainson R, et al. (1999). "The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling.". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 869–74. PMID 9927660.
Burren CP, Wilson EM, Hwa V, et al. (1999). "Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily.". J. Clin. Endocrinol. Metab. 84 (3): 1096–103. PMID 10084601.
Perbal B (1999). "Nuclear localisation of NOVH protein: a potential role for NOV in the regulation of gene expression.". MP, Mol. Pathol. 52 (2): 84–91. PMID 10474687.
Albrecht C, von Der Kammer H, Mayhaus M, et al. (2000). "Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61.". J. Biol. Chem. 275 (37): 28929–36. doi:10.1074/jbc.M003053200. PMID 10852911.
Martinerie C, Gicquel C, Louvel A, et al. (2001). "Altered expression of novH is associated with human adrenocortical tumorigenesis.". J. Clin. Endocrinol. Metab. 86 (8): 3929–40. PMID 11502835.
Manara MC, Perbal B, Benini S, et al. (2002). "The expression of ccn3(nov) gene in musculoskeletal tumors.". Am. J. Pathol. 160 (3): 849–59. PMID 11891184.
Sakamoto K, Yamaguchi S, Ando R, et al. (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.". J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162.
Li CL, Martinez V, He B, et al. (2002). "A role for CCN3 (NOV) in calcium signalling.". MP, Mol. Pathol. 55 (4): 250–61. PMID 12147716.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Thibout H, Martinerie C, Créminon C, et al. (2003). "Characterization of human NOV in biological fluids: an enzyme immunoassay for the quantification of human NOV in sera from patients with diseases of the adrenal gland and of the nervous system.". J. Clin. Endocrinol. Metab. 88 (1): 327–36. PMID 12519873.
Lin CG, Leu SJ, Chen N, et al. (2003). "CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family.". J. Biol. Chem. 278 (26): 24200–8. doi:10.1074/jbc.M302028200. PMID 12695522.
Ellis PD, Metcalfe JC, Hyvönen M, Kemp PR (2003). "Adhesion of endothelial cells to NOV is mediated by the integrins alphavbeta3 and alpha5beta1.". J. Vasc. Res. 40 (3): 234–43. doi:10.1159/000071887. PMID 12902636.
Laurent M, Martinerie C, Thibout H, et al. (2003). "NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism.". FASEB J. 17 (13): 1919–21. doi:10.1096/fj.02-1023fje. PMID 14519668.
Lombet A, Planque N, Bleau AM, et al.. "CCN3 and calcium signaling." 1 (1): 1. doi:10.1186/1478-811X-1-1. PMID 14606958.
Schild C, Trueb B (2004). "Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress.". Biochim. Biophys. Acta 1691 (1): 33–40. doi:10.1016/j.bbamcr.2003.12.001. PMID 15053922.
Gellhaus A, Dong X, Propson S, et al. (2004). "Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells.". J. Biol. Chem. 279 (35): 36931–42. doi:10.1074/jbc.M404073200. PMID 15181016.