Talk:Neuroleptic malignant syndrome

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From the public domain resource at http://www.ninds.nih.gov/health_and_medical/disorders/neuroleptic_syndrome.htm

[edit] NMS and Sinemet withdrawal?

I think NMS can also be caused by withdrawal from Sinemet, but I don't know enough about it to make the edit. Can a physician or other expert comment?

Sarah Waggoner 21:21, 26 September 2007 (UTC)

http://www.rxlist.com/cgi/generic/sinemet_wcp.htm It seems so - this source IS reliable, but I'm sure there are high quality ones.

It is also worth noting that the condition can occur on *withdrawing* from Neuroleptics (antipsychotics) too. Although some might say that it is 'Malignant Catatonia' in this case. And there may well be a crossover between NMS and Malignant Catatonia too! I might find sources later and add this to the article if not already there. Buckethed (talk) 01:04, 14 December 2007 (UTC)

[edit] Dubious

I question the validity of the statement "NMS should be ruled out in the case of acute behaviour change of any person on antipsychotic medication". Isn't the intended effect of antipsychotic medication to produce behavioural change, so a change in the behaviour of people starting treatment (the people most likely to be afflicted with NMS) shouldn't rule out anything — it should be expected. Neitherday (talk) 04:03, 17 December 2007 (UTC)

I just read it again and what I meant was:

Acute and significant behaviour change/deterioration (eg: over a day or less) in someone who has otherwise been stable for a period of time on antipsychotics. (i.e. the dose hasn't been changed and the person hasn't deteriorated because of drug-taking or noncompliance)

I'll get a ref and figure out the best way to word it exactly. Is that clearer? cheers, Casliber (talk · contribs) 04:38, 17 December 2007 (UTC)

I get it now, thank you. :) Neitherday (talk) 06:34, 17 December 2007 (UTC)

[edit] Fever vs Hyperthermia

The rise in core temperature is really hyperthermia due mostly to excessive muscle activity and not fever, although these two are frequently mixed up (even the mesh definition for Neuroleptic malignant syndrome says 'fever'). Maybe this should be changed, although the useful mnemonic would also need to be altered. —Preceding unsigned comment added by T vanhove (talk • contribs) 09:39, 30 December 2007 (UTC)