MYLK

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Myosin, light chain kinase
PDB rendering based on 2cqv.
Available structures: 2cqv
Identifiers
Symbol(s)	MYLK; DKFZp686I10125; FLJ12216; KRP; MLCK; MLCK108; MLCK210; MSTP083
External IDs	OMIM: 600922 MGI: 894806 HomoloGene: 14202
EC number	2.7.1.117
Gene ontology Molecular Function: • nucleotide binding • magnesium ion binding • myosin light chain kinase activity • signal transducer activity • calcium ion binding • calmodulin binding • ATP binding • kinase activity • transferase activity Biological Process: • protein amino acid phosphorylation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	4638	107589
Ensembl	ENSG00000065534	ENSMUSG00000022836
Uniprot	Q15746	Q8CIY5
Refseq	NM_005965 (mRNA) NP_005956 (protein)	NM_139300 (mRNA) NP_647461 (protein)
Location	Chr 3: 124.81 - 125.09 Mb	Chr 16: 34.74 - 34.92 Mb
Pubmed search	[1]	[2]

Myosin, light chain kinase, also known as MYLK, is a human gene.

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.^[1]

Contents 1 See also 2 References 3 Further reading 4 External links

[edit] See also

• Myosin light-chain kinase

[edit] References

[edit] Further reading

[edit] External links

• MeSH MYLK+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.