MYL6B

From Wikipedia, the free encyclopedia

Myosin, light chain 6B, alkali, smooth muscle and non-muscle

PDB rendering based on 1oe9.

Available structures: 1oe9, 1w7i, 1w7j

Identifiers

Symbol(s)

MYL6B; MLC1SA

External IDs

OMIM: 609930 MGI: 1917789 HomoloGene: 86887

Gene ontology
Molecular Function:	• motor activity • calcium ion binding • protein binding • structural constituent of muscle
Cellular Component:	• muscle myosin complex • unconventional myosin complex
Biological Process:	• striated muscle development • muscle filament sliding

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002475 (mRNA)
NP_002466 (protein)

XM_978382 (mRNA)
XP_983476 (protein)

Location

Chr 12: 54.83 - 54.84 Mb

Chr 10: 127.9 - 127.9 Mb

Pubmed search

[1]

[2]

Myosin, light chain 6B, alkali, smooth muscle and non-muscle, also known as MYL6B, is a human gene.^[1]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue.^[1]

[edit] References

^ ^a ^b Entrez Gene: MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle.

[edit] Further reading

Coureux PD, Sweeney HL, Houdusse A (2005). "Three myosin V structures delineate essential features of chemo-mechanical transduction.". EMBO J. 23 (23): 4527-37. doi:10.1038/sj.emboj.7600458. PMID 15510214.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Komiyama M, Soldati T, von Arx P, Perriard JC (1997). "The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition.". J. Cell. Sci. 109 ( Pt 8): 2089-99. PMID 8856505.
Zimmermann K, Starzinski-Powitz A (1990). "A novel isoform of myosin alkali light chain isolated from human muscle cells.". Nucleic Acids Res. 17 (24): 10496. PMID 2602161.
Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms.". Gene 66 (1): 135-46. PMID 2458299.
Hailstones DL, Gunning PW (1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function.". Mol. Cell. Biol. 10 (3): 1095-104. PMID 2304459.