MYL1

From Wikipedia, the free encyclopedia

Myosin, light chain 1, alkali; skeletal, fast

Identifiers

MYL1; MLC1F; MLC3F

External IDs

OMIM: 160780 MGI: 97269 HomoloGene: 23194

Gene ontology
Molecular Function:	• motor activity • calcium ion binding • structural constituent of muscle
Cellular Component:	• muscle myosin complex • myosin complex
Biological Process:	• muscle development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_079420 (mRNA)
NP_524144 (protein)

NM_021285 (mRNA)
NP_067260 (protein)

Location

Chr 2: 210.86 - 210.89 Mb

Chr 1: 66.86 - 66.88 Mb

Pubmed search

[1]

[2]

Myosin, light chain 1, alkali; skeletal, fast, also known as MYL1, is a human gene.^[1]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast.

[edit] Further reading

Kelly RG, Buckingham ME (2000). "Modular regulation of the MLC1F/3F gene and striated muscle diversity.". Microsc. Res. Tech. 50 (6): 510-21. doi:10.1002/1097-0029(20000915)50:6<510::AID-JEMT8>3.0.CO;2-1. PMID 10998640.
Hailstones DL, Gunning PW (1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function.". Mol. Cell. Biol. 10 (3): 1095-104. PMID 2304459.
Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms.". Gene 66 (1): 135-46. PMID 2458299.
Seidel U, Arnold HH (1989). "Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle.". J. Biol. Chem. 264 (27): 16109-17. PMID 2777779.
Cohen-Haguenauer O, Barton PJ, Nguyen VC, et al. (1988). "Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter.". Hum. Genet. 78 (1): 65-70. PMID 3422212.
Seidel U, Bober E, Winter B, et al. (1987). "The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3.". Nucleic Acids Res. 15 (12): 4989. PMID 3601661.
Kontrogianni-Konstantopoulos A, Huang SC, Benz EJ (2001). "A nonerythroid isoform of protein 4.1R interacts with components of the contractile apparatus in skeletal myofibers.". Mol. Biol. Cell 11 (11): 3805-17. PMID 11071908.
Ballweber E, Galla M, Aktories K, et al. (2001). "Interaction of ADP-ribosylated actin with actin binding proteins.". FEBS Lett. 508 (1): 131-5. PMID 11707283.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.