MUC5AC

From Wikipedia, the free encyclopedia

Mucin 5AC, oligomeric mucus/gel-forming

Identifiers

External IDs

Gene ontology
Molecular Function:	• molecular_function • structural constituent of ribosome • extracellular matrix structural constituent • extracellular matrix constituent, lubricant activity
Cellular Component:	• cellular_component • intracellular • ribosome • fibril
Biological Process:	• translation • cell adhesion • digestion • biological_process • fibril organization and biogenesis

Orthologs

Human

Mouse

Entrez

4586

n/a

Refseq

XM_001130382 (mRNA)
XP_001130382 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Mucin 5AC, oligomeric mucus/gel-forming, also known as MUC5AC, is a human gene.^[1]

[edit] References

^ Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming.

[edit] Further reading

Meezaman D, Charles P, Daskal E, et al. (1994). "Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).". J. Biol. Chem. 269 (17): 12932–9. PMID 7513696.
Lesuffleur T, Roche F, Hill AS, et al. (1995). "Characterization of a mucin cDNA clone isolated from HT-29 mucus-secreting cells. The 3' end of MUC5AC?". J. Biol. Chem. 270 (23): 13665–73. PMID 7775418.
Guyonnet Duperat V, Audie JP, Debailleul V, et al. (1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem. J. 305 ( Pt 1): 211–9. PMID 7826332.
Klomp LW, Van Rens L, Strous GJ (1997). "Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains.". Biochem. J. 308 ( Pt 3): 831–8. PMID 8948439.
Li D, Gallup M, Fan N, et al. (1998). "Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts.". J. Biol. Chem. 273 (12): 6812–20. PMID 9506983.
van de Bovenkamp JH, Hau CM, Strous GJ, et al. (1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif.". Biochem. Biophys. Res. Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
Buisine MP, Desseyn JL, Porchet N, et al. (1998). "Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family.". Biochem. J. 332 ( Pt 3): 729–38. PMID 9620876.
Tomasetto C, Masson R, Linares JL, et al. (2000). "pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins.". Gastroenterology 118 (1): 70–80. PMID 10611155.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome.". Science 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
Silverman HS, Parry S, Sutton-Smith M, et al. (2001). "In vivo glycosylation of mucin tandem repeats.". Glycobiology 11 (6): 459–71. PMID 11445551.
Escande F, Aubert JP, Porchet N, Buisine MP (2001). "Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region.". Biochem. J. 358 (Pt 3): 763–72. PMID 11535137.
Fischer BM, Voynow JA (2002). "Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species.". Am. J. Respir. Cell Mol. Biol. 26 (4): 447–52. PMID 11919081.
Nordman H, Davies JR, Lindell G, et al. (2002). "Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution.". Biochem. J. 364 (Pt 1): 191–200. PMID 11988092.
Nollet S, Forgue-Lafitte ME, Kirkham P, Bara J (2002). "Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: expression in normal GI tract and colon tumors.". Int. J. Cancer 99 (3): 336–43. doi:10.1002/ijc.10335. PMID 11992401.
Koo JS, Kim YD, Jetten AM, et al. (2002). "Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist.". Exp. Lung Res. 28 (4): 315–32. doi:10.1080/01902140252964393. PMID 12042033.
Guo JM, Zhang Y, Cheng L, et al. (2002). "Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12.". FEBS Lett. 524 (1-3): 211–8. PMID 12135769.
Kim GE, Bae HI, Park HU, et al. (2002). "Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas.". Gastroenterology 123 (4): 1052–60. PMID 12360467.
Kim YD, Kwon EJ, Park DW, et al. (2002). "Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells.". Mol. Pharmacol. 62 (5): 1112–8. PMID 12391274.
Cheng L, Tachibana K, Zhang Y, et al. (2002). "Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10.". FEBS Lett. 531 (2): 115–21. PMID 12417297.
Baldus SE, Mönig SP, Arkenau V, et al. (2003). "Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinoma.". Ann. Surg. Oncol. 9 (9): 887–93. PMID 12417511.