MST1

From Wikipedia, the free encyclopedia

Macrophage stimulating 1 (hepatocyte growth factor-like)

PDB rendering based on 2asu.

Available structures: 2asu

Identifiers

Symbol(s)

MST1; D3F15S2; DNF15S2; MSP; HGFL; NF15S2

External IDs

OMIM: 142408 MGI: 96080 HomoloGene: 7360

Gene ontology
Molecular Function:	• molecular_function • serine-type endopeptidase activity • calcium ion binding
Cellular Component:	• cellular_component
Biological Process:	• proteolysis • blood coagulation • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020998 (mRNA)
NP_066278 (protein)

NM_008243 (mRNA)
NP_032269 (protein)

Location

Chr 3: 49.7 - 49.7 Mb

Chr 9: 107.94 - 107.94 Mb

Pubmed search

[1]

[2]

Macrophage stimulating 1 (hepatocyte growth factor-like), also known as MST1, is a human gene.^[1]

[edit] References

^ Entrez Gene: MST1 macrophage stimulating 1 (hepatocyte growth factor-like).

[edit] Further reading

Han S, Stuart LA, Degen SJ (1991). "Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor.". Biochemistry 30 (40): 9768–80. PMID 1655021.
Skeel A, Yoshimura T, Showalter SD, et al. (1991). "Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity.". J. Exp. Med. 173 (5): 1227–34. PMID 1827141.
Gerber MJ, Drabkin HA, Firnhaber C, et al. (1988). "Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel.". Am. J. Hum. Genet. 43 (4): 442–51. PMID 2902784.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Yoshimura T, Yuhki N, Wang MH, et al. (1993). "Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.". J. Biol. Chem. 268 (21): 15461–8. PMID 8393443.
Waltz SE, Gould FK, Air EL, et al. (1996). "Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein.". J. Biol. Chem. 271 (15): 9024–32. PMID 8621550.
Creasy CL, Ambrose DM, Chernoff J (1996). "The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain.". J. Biol. Chem. 271 (35): 21049–53. PMID 8702870.
Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility.". J. Clin. Invest. 99 (4): 701–9. PMID 9045873.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Yoshikawa W, Hara H, Takehara T, et al. (1999). "Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein.". Arch. Biochem. Biophys. 363 (2): 356–60. doi:10.1006/abbi.1998.1090. PMID 10068459.
Degen SJ, McDowell SA, Waltz SE, et al. (2000). "Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.". DNA Seq. 8 (6): 409–13. PMID 10728827.
Skeel A, Leonard EJ (2001). "alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein.". J. Biol. Chem. 276 (24): 21932–7. doi:10.1074/jbc.M100652200. PMID 11274154.
Rampino T, Collesi C, Gregorini M, et al. (2002). "Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells.". J. Am. Soc. Nephrol. 13 (3): 649–57. PMID 11856768.
Zhou YQ, Chen YQ, Fisher JH, Wang MH (2002). "Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages.". J. Biol. Chem. 277 (41): 38104–10. doi:10.1074/jbc.M206167200. PMID 12177064.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration.". Dev. Cell 5 (2): 257–71. PMID 12919677.
Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation.". J. Biol. Chem. 279 (5): 3726–32. doi:10.1074/jbc.M309342200. PMID 14597639.
Matsuzaki S, Canis M, Pouly JL, et al. (2005). "The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis.". Mol. Hum. Reprod. 11 (5): 345–9. doi:10.1093/molehr/gah162. PMID 15764806.
Zalcenstein A, Weisz L, Stambolsky P, et al. (2006). "Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53.". Oncogene 25 (3): 359–69. doi:10.1038/sj.onc.1209061. PMID 16170349.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.