MSRA (gene)

From Wikipedia, the free encyclopedia

Methionine sulfoxide reductase A

Identifiers

External IDs

OMIM: 601250 MGI: 106916 HomoloGene: 5812

Gene ontology
Molecular Function:	• protein-methionine-S-oxide reductase activity • oxidoreductase activity
Biological Process:	• protein modification process • methionine metabolic process • response to oxidative stress • protein metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012331 (mRNA)
NP_036463 (protein)

NM_026322 (mRNA)
NP_080598 (protein)

Location

Chr 8: 9.95 - 10.32 Mb

Chr 14: 63.08 - 63.41 Mb

Pubmed search

[1]

[2]

Methionine sulfoxide reductase A, also known as MSRA, is a human gene.^[1]

This protein is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its proposed function is the repair of oxidative damage to proteins to restore biological activity.^[1]

[edit] References

^ ^a ^b Entrez Gene: MSRA methionine sulfoxide reductase A.

[edit] Further reading

Hansel A, Heinemann SH, Hoshi T (2005). "Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation.". Biochim. Biophys. Acta 1703 (2): 239–47. doi:10.1016/j.bbapap.2004.09.010. PMID 15680232.
Moskovitz J, Jenkins NA, Gilbert DJ, et al. (1996). "Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues.". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3205–8. PMID 8622914.
Kuschel L, Hansel A, Schönherr R, et al. (1999). "Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA).". FEBS Lett. 456 (1): 17–21. PMID 10452521.
Hansel A, Kuschel L, Hehl S, et al. (2002). "Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins.". FASEB J. 16 (8): 911–3. doi:10.1096/fj.01-0737fje. PMID 12039877.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Vougier S, Mary J, Friguet B (2003). "Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells.". Biochem. J. 373 (Pt 2): 531–7. doi:10.1042/BJ20030443. PMID 12693988.
Picot CR, Perichon M, Cintrat JC, et al. (2004). "The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts.". FEBS Lett. 558 (1-3): 74–8. doi:10.1016/S0014-5793(03)01530-8. PMID 14759519.
Kantorow M, Hawse JR, Cowell TL, et al. (2004). "Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress.". Proc. Natl. Acad. Sci. U.S.A. 101 (26): 9654–9. doi:10.1073/pnas.0403532101. PMID 15199188.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
De Luca A, Sacchetta P, Di Ilio C, Favaloro B (2006). "Identification and analysis of the promoter region of the human methionine sulphoxide reductase A gene.". Biochem. J. 393 (Pt 1): 321–9. doi:10.1042/BJ20050973. PMID 16162094.
Picot CR, Petropoulos I, Perichon M, et al. (2006). "Overexpression of MsrA protects WI-38 SV40 human fibroblasts against H2O2-mediated oxidative stress.". Free Radic. Biol. Med. 39 (10): 1332–41. doi:10.1016/j.freeradbiomed.2005.06.017. PMID 16257642.
Lee JW, Gordiyenko NV, Marchetti M, et al. (2006). "Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina.". Exp. Eye Res. 82 (5): 816–27. doi:10.1016/j.exer.2005.10.003. PMID 16364291.
Schallreuter KU, Rübsam K, Chavan B, et al. (2006). "Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus.". Biochem. Biophys. Res. Commun. 342 (1): 145–52. doi:10.1016/j.bbrc.2006.01.124. PMID 16480945.
Lei KF, Wang YF, Zhu XQ, et al. (2007). "Identification of MSRA gene on chromosome 8p as a candidate metastasis suppressor for human hepatitis B virus-positive hepatocellular carcinoma.". BMC Cancer 7: 172. doi:10.1186/1471-2407-7-172. PMID 17784942.