MHC class I polypeptide-related sequence A

From Wikipedia, the free encyclopedia

PDB rendering based on 1b3j.

Available structures: 1b3j, 1hyr

Identifiers

Symbol(s)

MICA; MGC111087; PERB11.1

External IDs

OMIM: 600169 MGI: 2179989 HomoloGene: 88329

Gene ontology
Molecular Function:	• protein binding • MHC class I receptor activity
Cellular Component:	• integral to plasma membrane • membrane • integral to membrane • MHC class I protein complex
Biological Process:	• antigen processing and presentation of peptide antigen via MHC class I • response to stress • immune response • cellular defense response • cell recognition • antigen processing and presentation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

XM_001124652 (mRNA)
XP_001124652 (protein)

XM_985890 (mRNA)
XP_990984 (protein)

Location

Chr c6_QBL: 31.5 - 31.52 Mb

n/a

Pubmed search

[1]

[2]

MHC class I polypeptide-related sequence A, also known as MICA, is a human gene.

MICA encodes the highly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells.^[1]

[edit] See also

[edit] References

^ Entrez Gene: MICA MHC class I polypeptide-related sequence A.

[edit] Further reading

Klein J, O'hUigin C (1994). "The conundrum of nonclassical major histocompatibility complex genes.". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6251-2. PMID 8022769.
Bahram S, Spies T (1997). "The MIC gene family.". Res. Immunol. 147 (5): 328-33. PMID 8876061.
Blumberg RS (1998). "Current concepts in mucosal immunity. II. One size fits all: nonclassical MHC molecules fulfill multiple roles in epithelial cell function.". Am. J. Physiol. 274 (2 Pt 1): G227-31. PMID 9486173.