Medullary interstitium

The medullary interstitium is the tissue surrounding the loop of Henle in the renal medulla.

It functions in renal water reabsorption by building up a high hypertonicity, which draws water out of the thin descending limb of the loop of Henle and the collecting duct system. This hypertonicity, in turn, is created by an efflux of urea from the inner medullary collecting duct.^[1].

[edit] References

^ Walter F., PhD. Boron (2003). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders, 1300. ISBN 1-4160-2328-3. Page 837

v • d • e Urinary system – Kidney

Layers	Renal fascia • Renal capsule • Renal cortex (Renal column) • Renal medulla (Renal sinus, Renal pyramids, medullary interstitium) • Renal lobe • Cortical lobule • Medullary ray • Nephron

Afferent circulation	Renal artery → Segmental arteries → Interlobar arteries → Arcuate arteries → Cortical radial arteries → Afferent arterioles → Renal corpuscle (Glomerulus, Bowman's capsule)

Renal tubule	Proximal tubule → Loop of Henle (Descending, Thin ascending, Thick ascending) → Distal convoluted tubule → Connecting tubule → Collecting ducts → Duct of Bellini → Renal papilla → Minor calyx → Major calyx → Renal pelvis → Ureter

Efferent circulation	Glomerulus → Efferent arterioles → Peritubular capillaries / Vasa recta → Arcuate vein → Interlobar veins → Renal vein

Juxtaglomerular apparatus	Macula densa • Juxtaglomerular cells • Extraglomerular mesangial cell

Filtration	Glomerular basement membrane • Podocyte • Filtration slits • Intraglomerular mesangial cell • Tubular fluid

Renal physiology	Acid base physiology • Fluid balance

v • d • e Urinary system, physiology: renal physiology and acid base physiology

Filtration	Renal blood flow - Ultrafiltration - Countercurrent exchange

Hormones affecting filtration	Antidiuretic hormone (ADH) - Aldosterone - Atrial natriuretic peptide

Secretion/clearance	Pharmacokinetics - Clearance of medications

Reabsorption	Solvent drag -Na⁺ - Cl^- -urea -glucose -oligopeptides -protein

Endocrine	Renin - Erythropoietin (EPO) - Calcitriol (Active vitamin D) - Prostaglandins

Assessing Renal function / Measures of dialysis	Glomerular filtration rate - Creatinine clearance - Renal clearance ratio - Urea reduction ratio - Kt/V - Standardized Kt/V - Hemodialysis product - PAH clearance (Effective renal plasma flow - Extraction ratio)

Acid base physiology	Fluid balance - Darrow Yannet diagram - Body water - Interstitial fluid - Extracellular fluid - Intracellular fluid/Cytosol - Plasma - Transcellular fluid - Base excess - Davenport diagram - Anion gap - Arterial blood gas

Buffering/compensation	Bicarbonate buffering system - Respiratory compensation - Renal compensation

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