McLafferty rearrangement
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The McLafferty rearrangement is a phenomenon observed in mass spectrometry. Usually, it is observed that a molecule containing a keto-group undergoes β-cleavage, with the gain of the γ-hydrogen atom. This rearrangement may take place by a radical or ionic mechanism.
The reaction was first published by the American chemist Fred McLafferty during his research in mass spectrometry in 1959. [1]
[edit] References
- Gross ML (2004). "Focus in honor of Fred McLafferty, 2003 Distinguished Contribution awardee, for the discovery of the "McLafferty Rearrangement"". J. Am. Soc. Mass Spectrom. 15 (7): 951–5. doi:. PMID 15234352.
- Nibbering NM (2004). "The McLafferty rearrangement: a personal recollection". J. Am. Soc. Mass Spectrom. 15 (7): 956–8. doi:. PMID 15234353.
