MAPK3

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Main article: Extracellular signal-regulated kinases

Mitogen-activated protein kinase 3

Identifiers

MAPK3; ERK1; HS44KDAP; HUMKER1A; MGC20180; P44ERK1; P44MAPK; PRKM3

External IDs

OMIM: 601795 MGI: 1346859 HomoloGene: 55682

Gene ontology
Molecular Function:	• nucleotide binding • phosphotyrosine binding • protein kinase activity • protein serine/threonine kinase activity • MAP kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• cellular_component • nucleus • cytoplasm
Biological Process:	• regulation of progression through cell cycle • protein amino acid phosphorylation • response to DNA damage stimulus • cell cycle • organ morphogenesis • sensory perception of pain

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001040056 (mRNA)
NP_001035145 (protein)

NM_011952 (mRNA)
NP_036082 (protein)

Location

Chr 16: 30.03 - 30.04 Mb

Chr 7: 126.55 - 126.56 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase 3, also known as MAPK3, is a human gene.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.^[1]

[edit] References

^ Entrez Gene: MAPK3 mitogen-activated protein kinase 3.

[edit] Further reading

Peruzzi F, Gordon J, Darbinian N, Amini S (2003). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway.". J. Neurovirol. 8 Suppl 2: 91–6. doi:10.1080/13550280290167885. PMID 12491158.
Meloche S, Pouysségur J (2007). "The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition.". Oncogene 26 (22): 3227–39. doi:10.1038/sj.onc.1210414. PMID 17496918.
Ruscica M, Dozio E, Motta M, Magni P (2007). "Modulatory actions of neuropeptide Y on prostate cancer growth: role of MAP kinase/ERK 1/2 activation.". Adv. Exp. Med. Biol. 604: 96–100. PMID 17695723.