MAFA (gene)

From Wikipedia, the free encyclopedia

V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)

Identifiers

MAFA; RIPE3b1; hMafA

External IDs

OMIM: 610303 MGI: 2673307 HomoloGene: 65867

Gene ontology
Molecular Function:	• transcription factor activity • protein homodimerization activity • sequence-specific DNA binding • protein heterodimerization activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • response to glucose stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_201589 (mRNA)
NP_963883 (protein)

XM_981620 (mRNA)
XP_986714 (protein)

Location

Chr 8: 144.58 - 144.58 Mb

Chr 15: 75.57 - 75.58 Mb

Pubmed search

[1]

[2]

V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian), also known as MAFA, is a human gene.^[1]

[edit] References

^ Entrez Gene: MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian).

[edit] Further reading

Benkhelifa S, Provot S, Nabais E, et al. (2001). "Phosphorylation of MafA is essential for its transcriptional and biological properties.". Mol. Cell. Biol. 21 (14): 4441-52. doi:10.1128/MCB.21.14.4441-4452.2001. PMID 11416124.
Olbrot M, Rud J, Moss LG, Sharma A (2002). "Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6737-42. doi:10.1073/pnas.102168499. PMID 12011435.
Kataoka K, Han SI, Shioda S, et al. (2003). "MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene.". J. Biol. Chem. 277 (51): 49903-10. doi:10.1074/jbc.M206796200. PMID 12368292.
Matsuoka TA, Artner I, Henderson E, et al. (2004). "The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2930-3. doi:10.1073/pnas.0306233101. PMID 14973194.
Kaneto H, Matsuoka TA, Nakatani Y, et al. (2005). "A crucial role of MafA as a novel therapeutic target for diabetes.". J. Biol. Chem. 280 (15): 15047-52. doi:10.1074/jbc.M412013200. PMID 15664997.
Harmon JS, Stein R, Robertson RP (2005). "Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells.". J. Biol. Chem. 280 (12): 11107-13. doi:10.1074/jbc.M410345200. PMID 15664999.
Zhao L, Guo M, Matsuoka TA, et al. (2005). "The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription.". J. Biol. Chem. 280 (12): 11887-94. doi:10.1074/jbc.M409475200. PMID 15665000.
Aramata S, Han SI, Yasuda K, Kataoka K (2005). "Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1.". Biochim. Biophys. Acta 1730 (1): 41-6. doi:10.1016/j.bbaexp.2005.05.009. PMID 15993959.
Raum JC, Gerrish K, Artner I, et al. (2006). "FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.". Mol. Cell. Biol. 26 (15): 5735-43. doi:10.1128/MCB.00249-06. PMID 16847327.