Mad1
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MAD1 mitotic arrest deficient-like 1 (yeast)
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| PDB rendering based on 1go4. | ||||||||||||||
| Available structures: 1go4 | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | MAD1L1; MAD1; HsMAD1; PIG9; TP53I9; TXBP181 | |||||||||||||
| External IDs | OMIM: 602686 MGI: 1341857 HomoloGene: 74500 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 8379 | 17120 | ||||||||||||
| Ensembl | ENSG00000002822 | ENSMUSG00000029554 | ||||||||||||
| Uniprot | Q9Y6D9 | Q9WTX8 | ||||||||||||
| Refseq | NM_001013836 (mRNA) NP_001013858 (protein) |
NM_010752 (mRNA) NP_034882 (protein) |
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| Location | Chr 7: 1.82 - 2.24 Mb | Chr 5: 140.26 - 140.57 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
MAD1 mitotic arrest deficient-like 1 (yeast), also known as MAD1L1, is a human gene.[1]
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.[1]
[edit] See also
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