M1G
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- The correct title of this article is M1G. It features superscript or subscript characters that are substituted or omitted because of technical limitations.
| M1G | |
|---|---|
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| IUPAC name | pyrimido[1,2-a]purin-10(3H)-one |
| Identifiers | |
| CAS number | [103408-45-3] |
| PubChem | |
| SMILES | C1=CN2C(=O)C3=C(N=CN3)N=C2N=C1 |
| Properties | |
| Molecular formula | C8H5N5O |
| Molar mass | 187.1582 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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M1G (pyrimido[1,2-a]purin-10(3H)-one) is a DNA adduct.[1] It is created by malondialdehyde (an end product of lipid peroxidation) and is mutagenic. It is repaired by the body by the nucleotide excision repair system.[2] If not repaired, the adduct is mutagenic. Therefore, detection and quantification of M1G adducts in the body is a tool for diagnosing cancer.[2]
It has been detected in cell DNA in liver, leucocytes, pancreas and breast in concentrations of 1-120 per 108 nucleotides.[2]
[edit] References
- ^ Seto H, Okuda T, Takesue T, Ikemura T (1983). "Reaction of Malonaldehyde with Nucleic Acid. I. Formation of Fluorescent Pyrimido[1,2-a]purin-10(3H)-one Nucleosides". Bulletin of the Chemical Society of Japan 56 (6): 1799–1802. doi:.
- ^ a b c Marnett LJ (1999). "Lipid peroxidation-DNA damage by malondialdehyde". Mutat. Res. 424 (1-2): 83–95. doi:. PMID 10064852.
[edit] External links
- MeSH pyrimido(1,2-a)purin-10(3H)-one
- MeSH 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)pyrimido(1,2-alpha)purin-10(3H)-one
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