Lycorine
From Wikipedia, the free encyclopedia
| Lycorine | |
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| IUPAC name | 1,2,4,5,12b,12c-Hexahydro-7H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol |
| Other names | Galanthidine, Amarylline, Narcissine, Licorine, Belamarine |
| Identifiers | |
| CAS number | [476-28-8] |
| PubChem | |
| SMILES | C1CN2CC3=CC4=C(C=C3C5C2C1=CC(C5O)O)OCO4 |
| Properties | |
| Molecular formula | C16H17NO4 |
| Molar mass | 287.31 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Lycorine is a toxic crystalline alkaloid found in several plant species, such as the bush lily (Clivia miniata), Lycoris, and Narcissus. It may be highly poisonous, if not lethal, when ingested in certain quantities. Symptoms of lycorine toxicity are vomiting, diarrhea, and convulsions.[1] Regardless, it is sometimes used medicinally, a reason why some groups may harvest the very popular Clivia miniata.
It inhibits protein synthesis,[2] and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
Presently, it serves some interest in the study of certain yeasts, the principal organism on which lycorine is tested.[3]
Lycorine is also found in daffodil bulbs which are often confused with onions.
[edit] External links
- ^ Lycorine, definition at mercksource.com
- ^ Vrijsen R, Vanden Berghe DA, Vlietinck AJ, Boeyé A (1986). "Lycorine: a eukaryotic termination inhibitor?". J. Biol. Chem. 261 (2): 505–7. PMID 3001065.
- ^ Garuccio I, Arrigoni O (1989). "[Various sensitivities of yeasts to lycorine]" (in Italian). Boll. Soc. Ital. Biol. Sper. 65 (6): 501–8. PMID 2611011.
