KIF22

From Wikipedia, the free encyclopedia

Kinesin family member 22

Identifiers

KIF22; KID; KNSL4; OBP; OBP-1; OBP-2

External IDs

OMIM: 603213 MGI: 109233 HomoloGene: 32011

Gene ontology
Molecular Function:	• nucleotide binding • microtubule motor activity • ATP binding • sequence-specific DNA binding
Cellular Component:	• kinetochore • intracellular • nucleus • microtubule • microtubule associated complex
Biological Process:	• microtubule-based movement • mitosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007317 (mRNA)
NP_015556 (protein)

NM_145588 (mRNA)
NP_663563 (protein)

Location

Chr 16: 29.71 - 29.72 Mb

Chr 7: 126.82 - 126.83 Mb

Pubmed search

[1]

[2]

Kinesin family member 22, also known as KIF22, is a human gene.^[1]

The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance.^[1]

[edit] References

^ ^a ^b Entrez Gene: KIF22 kinesin family member 22.

[edit] Further reading

Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004-11. doi:10.1073/pnas.111145398. PMID 11416179.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Zhang S, Nonoyama M (1994). "The cellular proteins that bind specifically to the Epstein-Barr virus origin of plasmid DNA replication belong to a gene family.". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2843-7. PMID 8146198.
Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, et al. (1996). "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle.". EMBO J. 15 (3): 457-67. PMID 8599929.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Song J, Murakami H, Tsutsui H, et al. (1998). "Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ).". J. Biol. Chem. 273 (32): 20603-14. PMID 9685418.
Song J, Murakami H, Yang ZQ, et al. (1998). "Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2.". Genomics 52 (3): 374-7. doi:10.1006/geno.1998.5452. PMID 9790757.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295-308. doi:10.1006/geno.1999.5927. PMID 10493829.
Funabiki H, Murray AW (2000). "The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement.". Cell 102 (4): 411-24. PMID 10966104.
Antonio C, Ferby I, Wilhelm H, et al. (2000). "Xkid, a chromokinesin required for chromosome alignment on the metaphase plate.". Cell 102 (4): 425-35. PMID 10966105.
Germani A, Bruzzoni-Giovanelli H, Fellous A, et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.". Oncogene 19 (52): 5997-6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
Levesque AA, Compton DA (2001). "The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles.". J. Cell Biol. 154 (6): 1135-46. doi:10.1083/jcb.200106093. PMID 11564754.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yajima J, Edamatsu M, Watai-Nishii J, et al. (2003). "The human chromokinesin Kid is a plus end-directed microtubule-based motor.". EMBO J. 22 (5): 1067-74. doi:10.1093/emboj/cdg102. PMID 12606572.
Shiroguchi K, Ohsugi M, Edamatsu M, et al. (2003). "The second microtubule-binding site of monomeric kid enhances the microtubule affinity.". J. Biol. Chem. 278 (25): 22460-5. doi:10.1074/jbc.M212274200. PMID 12692123.
Ohsugi M, Tokai-Nishizumi N, Shiroguchi K, et al. (2003). "Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes.". EMBO J. 22 (9): 2091-103. doi:10.1093/emboj/cdg208. PMID 12727876.
Venkatesh LK, Gettemeier T, Chinnadurai G (2003). "A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein.". J. Virol. 77 (13): 7236-43. PMID 12805422.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Tokai-Nishizumi N, Ohsugi M, Suzuki E, Yamamoto T (2006). "The chromokinesin Kid is required for maintenance of proper metaphase spindle size.". Mol. Biol. Cell 16 (11): 5455-63. doi:10.1091/mbc.E05-03-0244. PMID 16176979.