Keratin 18

From Wikipedia, the free encyclopedia

Keratin 18

Identifiers

KRT18; CYK18; K18

External IDs

OMIM: 148070 MGI: 96692 HomoloGene: 55448

Gene ontology
Molecular Function:	• structural constituent of cytoskeleton • protein binding
Cellular Component:	• intermediate filament
Biological Process:	• anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000224 (mRNA)
NP_000215 (protein)

NM_010664 (mRNA)
NP_034794 (protein)

Location

Chr 12: 51.63 - 51.63 Mb

Chr 15: 101.86 - 101.86 Mb

Pubmed search

[1]

[2]

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.^[1]

[edit] References

^ Entrez Gene: KRT18 keratin 18.

[edit] Further reading

Omary MB, Baxter GT, Chou CF, et al. (1992). "PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.". J. Cell Biol. 117 (3): 583-93. doi:10.1083/jcb.117.3.583. PMID 1374067.
Waseem A, Gough AC, Spurr NK, Lane EB (1990). "Localization of the gene for human simple epithelial keratin 18 to chromosome 12 using polymerase chain reaction.". Genomics 7 (2): 188-94. doi:10.1016/0888-7543(90)90540-B. PMID 1693358.
Heath P, Elvin P, Jenner D, et al. (1990). "Localisation of a cDNA clone for human cytokeratin 18 to chromosome 17p11-p12 by in situ hybridisation.". Hum. Genet. 85 (6): 669-70. doi:10.1007/BF00193596. PMID 1699878.
Waseem A, Alexander CM, Steel JB, Lane EB (1991). "Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs.". New Biol. 2 (5): 464-78. PMID 1705144.
Romano V, Hatzfeld M, Magin TM, et al. (1986). "Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone.". Differentiation 30 (3): 244-53. PMID 2422083.
Oshima RG, Millán JL, Ceceña G (1987). "Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation.". Differentiation 33 (1): 61-8. doi:10.1111/j.1432-0436.1987.tb01542.x. PMID 2434380.
Leube RE, Bosch FX, Romano V, et al. (1987). "Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ.". Differentiation 33 (1): 69-85. PMID 2434381.
Kulesh DA, Oshima RG (1988). "Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells.". Mol. Cell. Biol. 8 (4): 1540-50. PMID 2454392.
Sémat A, Vasseur M, Maillet L, et al. (1988). "Sequence analysis of murine cytokeratin endo A (no. 8) cDNA. Evidence for mRNA species initiated upstream of the normal 5' end in PCC4 cells.". Differentiation 37 (1): 40-6. doi:10.1111/j.1432-0436.1988.tb00794.x. PMID 2454862.
Kulesh DA, Oshima RG (1989). "Complete structure of the gene for human keratin 18.". Genomics 4 (3): 339-47. doi:10.1016/0888-7543(89)90340-6. PMID 2469635.
Ku NO, Omary MB (1994). "Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization.". J. Cell Biol. 127 (1): 161-71. doi:10.1083/jcb.127.1.161. PMID 7523419.
Liao J, Lowthert LA, Ghori N, Omary MB (1995). "The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner.". J. Biol. Chem. 270 (2): 915-22. PMID 7529764.
Yoon SJ, LeBlanc-Straceski J, Ward D, et al. (1995). "Organization of the human keratin type II gene cluster at 12q13.". Genomics 24 (3): 502-8. doi:10.1006/geno.1994.1659. PMID 7536183.
Ku NO, Omary MB (1995). "Identification and mutational analysis of the glycosylation sites of human keratin 18.". J. Biol. Chem. 270 (20): 11820-7. PMID 7538124.
Neumaier M, Gerhard M, Wagener C (1995). "Diagnosis of micrometastases by the amplification of tissue-specific genes.". Gene 159 (1): 43-7. doi:10.1016/0378-1119(94)00522-T. PMID 7541767.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Liao J, Lowthert LA, Ku NO, et al. (1996). "Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues.". J. Cell Biol. 131 (5): 1291-301. PMID 8522590.
Ku NO, Wright TL, Terrault NA, et al. (1997). "Mutation of human keratin 18 in association with cryptogenic cirrhosis.". J. Clin. Invest. 99 (1): 19-23. doi:10.1172/JCI119127. PMID 9011570.
Ji H, Reid GE, Moritz RL, et al. (1997). "A two-dimensional gel database of human colon carcinoma proteins.". Electrophoresis 18 (3-4): 605-13. doi:10.1002/elps.1150180344. PMID 9150948.

This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it.

v • d • e Protein: fibrous proteins

Collagen	Type-I (COL1A1) - Type-II (COL2A1) - Type-III - Type-IV - Type-V - Type XI (COL11A2) - Type-XVII - Type-XVIII

Keratin/Cytokeratin	type I (10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21), type II (1, 2A, 3, 4, 5, 6A, 7, 8, 9), Hair (Type I, Type II), Beta

other	Elastin - Cytoskeletal