Talk:Imatinib

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June 2, 2004 Featured article candidate Not promoted

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Contents 1 older entries 2 Follow-up 3 Reference was inserted 4 Heart failure 5 Image 6 India 7 Impact of HSCT 8 heart failure

[edit] older entries

Sodium, my compliments on your additions. Please note that in the image, Image:Mechanism imatinib.jpg, the name "Gleevec" is misspelled as "Gleevac". In case you're realllly bored :-) JFW | T@lk 22:40, 24 Apr 2004 (UTC)

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The story on Imatinib is getting interesting beyond cancer biology. Please see: Imatinib_Attenuates_Diabetes-Associated_Atherosclerosis. M. Lassila et al., Arteriosclerosis, Thrombosis, and Vascular Biology. 2004; 24: 935 - 942 PFHLai 07:25, 2004 May 9 (UTC)

This is getting very interesting! If there are more articles being published, it might merit inclusion in the imatinib article! PS I'm going to nominate this article as a Featured article.
JFW | T@lk 09:01, 9 May 2004 (UTC)

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In accordance with Wikipedia:WikiProject_Drugs naming policy, I propose we move this page to the INN Imatinib mesylate. If you have any concern with this proposal, please discuss it on this page. Matt 17:46, 23 Dec 2004 (UTC)

I'll do it now :-) JFW | T@lk 18:25, 23 Dec 2004 (UTC)

Heh, after discussing it at wikiproject_drugs, I agree that it should stay at imatinib, and I'll change the drug list to reflect this. Matt 21:23, 23 Dec 2004 (UTC)

Done, and I've added a redirect for imatinib mesilate as well. Techelf 03:49, 22 Mar 2005 (UTC)

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INN is Imatinib mesilate, not mesylate. In fact, it is mesylate salt, but INN uses "i" in similar names. Shouldn't we change it ? --Mykhal 18:20, 9 Jan 2005 (UTC)

The Novartis documentation refers to it as 'imatinib mesylate'. Is there a standard wikipedia policy on whether the INN or USAN (if either) should be followed? --moof 18:08, 1 February 2006 (UTC)

[edit] Follow-up

PMID 15677719: this agent works in imatinib resistance, but only in animal models. I suggest we wait until it has reached Phase III stages. JFW | T@lk 16:49, 28 Feb 2005 (UTC)

The added comment about smallpox is in this advance online publication article. We need to monitor when it appears in print to include the reference. JFW | T@lk 29 June 2005 15:27 (UTC)

[edit] Reference was inserted

TAYLOR, J. R., BROWNLOW, N., DOMIN, J. & DIBB, N. J. (2006) FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance. Oncogene, 25, 147-51.

This was inserted into the article. I'm not sure whether it is necessary to mention this in the article. JFW | T@lk 14:05, 17 January 2006 (UTC)

[edit] Heart failure

doi:10.1038/nm1446 - oops. JFW | T@lk 10:26, 28 July 2006 (UTC)

[edit] Image

Would anyone object to my replacing the current JPG image of c-abl kinase with a PNG version? Both versions for comparison:

Current image

PNG version

If there are no objections I'll go ahead and change it. I would boldly do so right now, but after seeing the current image has been in place for well over a year, I thought it best to ask first. Thanks, Fvasconcellos 14:35, 8 November 2006 (UTC)

No objections after two days, I'm changing it. Again, if anyone would like to revert to the previous version, go ahead, or leave a message on my Talk page. Fvasconcellos 13:16, 10 November 2006 (UTC)

[edit] India

PMID 17287473 - legal analysis on patenting of drugs in India. JFW | T@lk 21:26, 13 February 2007 (UTC)

[edit] Impact of HSCT

Less transplants thanks to imatinib doi:10.1111/j.1365-2141.2007.06582.x JFW | T@lk 22:58, 2 May 2007 (UTC)

[edit] heart failure

Actually relatively rare in imatinib use PMID 17449798 JFW | T@lk 06:40, 7 August 2007 (UTC)