Idebenone

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Idebenone
Systematic (IUPAC) name
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl- cyclohexa-2,5-diene-1,4-dione
Identifiers
CAS number	58186-27-9
ATC code	N06BX13
PubChem	3686
Chemical data
Formula	C19H30O5
Mol. mass	338.439 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	18 hours
Excretion	urine and feces
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Idebenone (pronounced eye-deb-eh-known) is an organic compound of the quinone family and promoted commercially as a synthetic analog of Coenzyme Q₁₀ (CoQ₁₀).

Idebenone is claimed to have properties similar to CoQ₁₀ in its antioxidant properties.^[specify]

Idebenone is different from Coenzyme Q₁₀ in one very important way. During a hypoxic (low oxygen) condition, CoQ₁₀ can switch function from an anti-oxidizing to an auto-oxidizing process. This auto-oxidation rapidly produces free radicals which damage the tissues of the body.^{[verification needed]}

Idebenone is said to perform the same functions as CoQ₁₀ without the risk of an auto-oxidation reaction.^{[verification needed]}

Idebenone is said to promote NGF (nerve growth factor) in the brain.^{[verification needed]} It appears to reduce tinnitus (ringing in the ears).^{[verification needed]} Idebenone has also been used in topical applications to treat wrinkles.

Takeda Pharmaceuticals studied Idebenone which it got approved for Alzheimer's disease and Stroke.

Idebenone has reduced the rate of deterioration of cardiac function in patients with Friedreich's ataxia (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12771265&ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum)

[edit] See also

• Free-radical theory of aging

[edit] External links

All citations may be verified via the following link, save for the bit regarding tinnitus: http://internaf.org/ataxia/Idebenone_desc.html

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