Hesperidin
From Wikipedia, the free encyclopedia
| Hesperidin | |
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| Identifiers | |
| CAS number | [520-26-3] |
| PubChem | |
| Properties | |
| Molecular formula | C28H34O15 |
| Molar mass | 610.56056 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Hesperidin is a flavonone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin. Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies.[1] In human nutrition it contributes to the integrity of the blood vessels.
Various preliminary studies reveal novel pharmaceutical properties. Hesperidin reduced cholesterol[2] and blood pressure[3] in rats. In a mouse study large doses of the glucoside hesperidin decreased bone density loss.[4] Another animal study showed protective effects against sepsis.[5] Hesperitin has anti-inflammatory effects.[6][7]
Some in vitro results applied only to the aglucone form. Hesperitin also showed the ability to penetrate the blood brain barrier in an in vitro model.[8]
[edit] References
- ^ Kinetics of radical-scavenging activity of hespere...[Anticancer Res. 2005 Sep-Oct] - PubMed Result
- ^ Biological effects of hesperidin, a Citrus flavono...[Farmaco. 1995] - PubMed Result
- ^ Glucosyl hesperidin improves serum cholesterol com...[J Nutr Sci Vitaminol (Tokyo). 2003] - PubMed Result
- ^ Hesperidin, a citrus flavonoid, inhibits bone loss...[J Nutr. 2003] - PubMed Result
- ^ A citrus flavonoid hesperidin suppresses infection...[Biol Pharm Bull. 2004] - PubMed Result
- ^ Pharmacological evaluation of the anti-inflammator...[J Pharm Pharmacol. 1994] - PubMed Result
- ^ Biological effects of hesperidin, a citrus flavono...[Farmaco. 1994] - PubMed Result
- ^ Interaction between flavonoids and the blood-brain...[J Neurochem. 2003] - PubMed Result
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