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| Hepatitis A virus internal ribosome entry site (IRES) |
 |
| Type: |
Cis-reg; IRES; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
[1] |
| Avg length: |
389.0 nucleotides |
| Avg identity: |
95% |
|
This family represents the internal ribosome entry site (IRES) of the the Hepatitis A virus.[1] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for eukaryotic initiation factor, eIF4F.[2]
[edit] References
- ^ Brown, EA; Zajac AJ, Lemon SM (1994). "In vitro characterization of an internal ribosomal entry site (IRES) present within the 5' nontranslated region of hepatitis A virus RNA: comparison with the IRES of encephalomyocarditis virus". J Virol 68: 1066–1074. PMID 8289336.
- ^ Kolupaeva, VG; Pestova TV, Hellen CU (2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA 6: 1791–1807. doi:10.1017/S1355838200000662. PMID 11142379.
[edit] External links
