Guido Brignone (6 December 1886 - 6 March 1959) was an Italian film director. He was the father of actress Lilla Brignone.
Brignone was born in Milan, Italy. He was the first Italian Director to win the Venice Film Festival or Mostra Internazionale d'Arte Cinematografica, the oldest film festival in the world, with Best Italian Film, Teresa Confalonieri (1934).
He died in Rome in 1959.
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