GP2 (gene)

From Wikipedia, the free encyclopedia

Glycoprotein 2 (zymogen granule membrane)

Identifiers

GP2; DKFZp779K0533; ZAP75

External IDs

OMIM: 602977 MGI: 1914383 HomoloGene: 1151

Gene ontology
Molecular Function:	• GPI anchor binding
Cellular Component:	• membrane fraction • membrane

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001007240 (mRNA)
NP_001007241 (protein)

NM_025989 (mRNA)
NP_080265 (protein)

Location

Chr 16: 20.23 - 20.25 Mb

Chr 7: 119.23 - 119.25 Mb

Pubmed search

[1]

[2]

Glycoprotein 2 (zymogen granule membrane), also known as GP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: GP2 glycoprotein 2 (zymogen granule membrane).

[edit] Further reading

Jacob M, Lainé J, LeBel D (1993). "Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase.". Biochem. Cell Biol. 70 (10-11): 1105–14. PMID 1284286.
Fukuoka S, Freedman SD, Yu H, et al. (1992). "GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1189–93. PMID 1531535.
Paul E, Leblond FA, LeBel D (1991). "In resting conditions, the pancreatic granule membrane protein GP-2 is secreted by cleavage of its glycosylphosphatidylinositol anchor.". Biochem. J. 277 ( Pt 3): 879–81. PMID 1651706.
Fukuoka S, Freedman SD, Scheele GA (1991). "A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes.". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2898–902. PMID 2011597.
Rindler MJ, Hoops TC (1991). "The pancreatic membrane protein GP-2 localizes specifically to secretory granules and is shed into the pancreatic juice as a protein aggregate.". Eur. J. Cell Biol. 53 (1): 154–63. PMID 2076702.
Hoops TC, Ivanov I, Cui Z, et al. (1994). "Incorporation of the pancreatic membrane protein GP-2 into secretory granules in exocrine but not endocrine cells.". J. Biol. Chem. 268 (34): 25694–705. PMID 7503984.
Freedman SD, Sakamoto K, Scheele GA (1994). "Nonparallel secretion of GP-2 from exocrine pancreas implies luminal coupling between acinar and duct cells.". Am. J. Physiol. 267 (1 Pt 1): G40–51. PMID 7519402.
Wong SM, Lowe AW (1996). "Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas.". Gene 171 (2): 311–2. PMID 8666297.
Fukuoka SI, Suzuki M, Okabayashi K, Takahashi E (1998). "Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization.". Cytogenet. Cell Genet. 79 (3-4): 231–2. PMID 9605860.
Fukuoka S (2000). "Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane-associated protein GP2.". Biochim. Biophys. Acta 1491 (1-3): 376–80. PMID 10760606.
Parker EM, Zaman MM, Freedman SD (2001). "GP2, a GPI-anchored protein in the apical plasma membrane of the pancreatic acinar cell, co-immunoprecipitates with src kinases and caveolin.". Pancreas 21 (3): 219–25. PMID 11039464.
Kalus I, Hodel A, Koch A, et al. (2002). "Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains.". Biochem. J. 362 (Pt 2): 433–42. PMID 11853552.
Tsujii-Hayashi Y, Kitahara M, Yamagaki T, et al. (2003). "A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes.". J. Biol. Chem. 277 (49): 47493–9. doi:10.1074/jbc.M206572200. PMID 12324456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tamiya G, Shinya M, Imanishi T, et al. (2005). "Whole genome association study of rheumatoid arthritis using 27 039 microsatellites.". Hum. Mol. Genet. 14 (16): 2305–21. doi:10.1093/hmg/ddi234. PMID 16000323.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.