GNB4
From Wikipedia, the free encyclopedia
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Guanine nucleotide binding protein (G protein), beta polypeptide 4
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| PDB rendering based on 1a0r. | |||||||||||
| Available structures: 1a0r, 1b9x, 1b9y, 1gg2, 1got, 1gp2, 1omw, 1tbg, 1xhm, 2bcj, 2trc | |||||||||||
| Identifiers | |||||||||||
| Symbol(s) | GNB4; | ||||||||||
| External IDs | MGI: 104581 HomoloGene: 69140 | ||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 59345 | 14696 | |||||||||
| Ensembl | ENSG00000114450 | ENSMUSG00000027669 | |||||||||
| Uniprot | Q9HAV0 | Q3THF3 | |||||||||
| Refseq | NM_021629 (mRNA) NP_067642 (protein) |
NM_013531 (mRNA) NP_038559 (protein) |
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| Location | Chr 3: 180.6 - 180.65 Mb | Chr 3: 32.78 - 32.81 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
Guanine nucleotide binding protein (G protein), beta polypeptide 4, also known as GNB4, is a human gene.[1]
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.[1]
[edit] References
[edit] Further reading
- Downes GB, Gautam N (2000). "The G protein subunit gene families.". Genomics 62 (3): 544-52. doi:. PMID 10644457.
- Pietruck F, Moritz A, Montemurro M, et al. (1996). "Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated.". Circ. Res. 79 (5): 974-83. PMID 8888689.
- Asano T, Morishita R, Ueda H, Kato K (1999). "Selective association of G protein beta(4) with gamma(5) and gamma(12) subunits in bovine tissues.". J. Biol. Chem. 274 (30): 21425-9. PMID 10409705.
- Huang L, Shanker YG, Dubauskaite J, et al. (2000). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.". Nat. Neurosci. 2 (12): 1055-62. doi:. PMID 10570481.
- Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB (2001). "Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq.". J. Biol. Chem. 276 (26): 23945-53. doi:. PMID 11294873.
- Ruiz-Velasco V, Ikeda SR, Puhl HL (2002). "Cloning, tissue distribution, and functional expression of the human G protein beta 4-subunit.". Physiol. Genomics 8 (1): 41-50. doi:. PMID 11842130.
- Huang L, Max M, Margolskee RF, et al. (2003). "G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells.". J. Comp. Neurol. 455 (1): 1-10. doi:. PMID 12454992.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta.". J. Biol. Chem. 278 (9): 7220-6. doi:. PMID 12486123.
- Sprague RS, Bowles EA, Olearczyk JJ, et al. (2003). "The role of G protein beta subunits in the release of ATP from human erythrocytes.". J. Physiol. Pharmacol. 53 (4 Pt 1): 667-74. PMID 12512701.
- Rosskopf D, Nikula C, Manthey I, et al. (2003). "The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction.". FEBS Lett. 544 (1-3): 27-32. PMID 12782285.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
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