GMP synthase

From Wikipedia, the free encyclopedia

Guanine monphosphate synthetase

Identifiers

External IDs

OMIM: 600358 MGI: 2448526 HomoloGene: 68367

Gene ontology
Molecular Function:	• nucleotide binding • GMP synthase activity • GMP synthase (glutamine-hydrolyzing) activity • ATP binding • ligase activity
Biological Process:	• purine nucleotide biosynthetic process • GMP biosynthetic process • glutamine metabolic process • biosynthetic process • purine base biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003875 (mRNA)
NP_003866 (protein)

NM_001033300 (mRNA)
NP_001028472 (protein)

Location

Chr 3: 157.07 - 157.14 Mb

n/a

Pubmed search

[1]

[2]

Guanine monphosphate synthetase, also known as GMPS is an enzyme that converts xanthosine monophosphate to guanosine monophosphate.^[1]

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.^[1]

[edit] References

^ ^a ^b Entrez Gene: GMPS guanine monphosphate synthetase.

[edit] Further reading

Page T, Bakay B, Nyhan WL (1984). "Human GMP synthetase.". Int. J. Biochem. 16 (1): 117–20. PMID 6698284.
Nakamura J, Straub K, Wu J, Lou L (1995). "The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine.". J. Biol. Chem. 270 (40): 23450–5. PMID 7559506.
Nakamura J, Lou L (1995). "Biochemical characterization of human GMP synthetase.". J. Biol. Chem. 270 (13): 7347–53. PMID 7706277.
Hirst M, Haliday E, Nakamura J, Lou L (1994). "Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA.". J. Biol. Chem. 269 (38): 23830–7. PMID 8089153.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Fedorova L, Kost-Alimova M, Gizatullin RZ, et al. (1997). "Assignment and ordering of twenty-three unique NotI-linking clones containing expressed genes including the guanosine 5'-monophosphate synthetase gene to human chromosome 3.". Eur. J. Hum. Genet. 5 (2): 110–6. PMID 9195163.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Pegram LD, Megonigal MD, Lange BJ, et al. (2001). "t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE) gene.". Blood 96 (13): 4360–2. PMID 11110714.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.

[edit] External links

MeSH GMP+synthase

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v • d • e Enzymes: ligases (EC 6)

6.1 - Carbon-Oxygen	Aminoacyl tRNA synthetase

6.2 - Carbon-Sulfur	Succinyl coenzyme A synthetase - Acetyl Co-A synthetase - Long fatty acyl CoA synthetase

6.3 - Carbon-Nitrogen	Glutamine synthetase - Ubiquitin ligase (Von Hippel-Lindau tumor suppressor, UBE3A, Mdm2, Anaphase-promoting complex) - Glutathione synthetase - CTP synthase - Adenylosuccinate synthase - Argininosuccinate synthetase - Holocarboxylase synthetase - GMP synthase - Asparagine synthetase - Carbamoyl phosphate synthetase (I, II) - Gamma-glutamylcysteine synthetase

6.4 - Carbon-Carbon	Carbon-carbon ligases

6.5 - Phosphoric Ester	DNA ligase

v • d • e

Metabolism: amino acid metabolism - nucleotide enzymes

Purine metabolism

Anabolism	synthesis: Amidophosphoribosyltransferase - Inosine monophosphate synthase GMP (IMP dehydrogenase, GMP synthase, GMP reductase) AMP (Adenylosuccinate synthase, Adenylosuccinate lyase, AMP deaminase)

Nucleotide salvage	Hypoxanthine-guanine phosphoribosyltransferase - Adenine phosphoribosyltransferase

Catabolism	Adenosine deaminase - Purine nucleoside phosphorylase - Guanine deaminase - Xanthine oxidase - Urate oxidase

Pyrimidine metabolism

Anabolism	CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase) Dihydroorotate dehydrogenase - Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase CTP synthase

Catabolism	Dihydropyrimidine dehydrogenase - Dihydropyrimidinase/DPYS - Beta-ureidopropionase/UPB1