GMP phosphodiesterase, delta subunit
From Wikipedia, the free encyclopedia
 |
||
| Membrane-bound ADP ribosylation factor-like protein 2 (ARL2 mouse, red), complex with phosphodiesterase delta (yellow) (1ksg) Blue dots show hydrocarbon boundary of the lipid bilayer | ||
| GMP-PDE, delta subunit | ||
|---|---|---|
| Identifiers | ||
| Symbol | GMP_PDE_delta | |
| Pfam | PF05351 | |
| InterPro | IPR008015 | |
| SCOP | 1ksj | |
| OPM protein | 1ksg | |
| Available PDB structures: | ||
GMP-PDE delta subunit was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE) (EC 3.1.4.35). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport[1].
[edit] Human proteins containing this domain
[edit] References
- ^ Wittinghofer A, Renault L, Hanzal-bayer M, Roversi P, Hillig RC (2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095–2106. doi:. PMID 11980706.
This article includes text from the public domain Pfam and InterPro IPR008015
