GGH (gene)

From Wikipedia, the free encyclopedia

Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)

PDB rendering based on 1l9x.

Available structures: 1l9x

Identifiers

Symbol(s)

GGH; GH

External IDs

OMIM: 601509 MGI: 1329035 HomoloGene: 2881

Gene ontology
Molecular Function:	• exopeptidase activity • gamma-glutamyl hydrolase activity • hydrolase activity
Cellular Component:	• lysosome
Biological Process:	• glutamine metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003878 (mRNA)
NP_003869 (protein)

NM_010281 (mRNA)
NP_034411 (protein)

Location

Chr 8: 64.09 - 64.11 Mb

n/a

Pubmed search

[1]

[2]

Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase), also known as GGH, is a human gene.^[1]

This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.^[1]

[edit] References

^ ^a ^b Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase).

[edit] Further reading

Galivan J, Ryan T, Rhee M, et al. (1999). "Glutamyl hydrolase: properties and pharmacologic impact.". Semin. Oncol. 26 (2 Suppl 6): 33–7. PMID 10598552.
O'Connor BM, Rotundo RF, Nimec Z, et al. (1991). "Secretion of gamma-glutamyl hydrolase in vitro.". Cancer Res. 51 (15): 3874–81. PMID 1713122.
Chandler CJ, Wang TT, Halsted CH (1986). "Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization.". J. Biol. Chem. 261 (2): 928–33. PMID 2867095.
Wang TT, Chandler CJ, Halsted CH (1986). "Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization.". J. Biol. Chem. 261 (29): 13551–5. PMID 3759978.
Yao R, Nimec Z, Ryan TJ, Galivan J (1996). "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase.". J. Biol. Chem. 271 (15): 8525–8. PMID 8621474.
Yao R, Schneider E, Ryan TJ, Galivan J (1996). "Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro.". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10134–8. PMID 8816764.
Rhee MS, Lindau-Shepard B, Chave KJ, et al. (1998). "Characterization of human cellular gamma-glutamyl hydrolase.". Mol. Pharmacol. 53 (6): 1040–6. PMID 9614206.
Yin D, Chave KJ, Macaluso CR, et al. (1999). "Structural organization of the human gamma-glutamyl hydrolase gene.". Gene 238 (2): 463–70. PMID 10570974.
Li H, Ryan TJ, Chave KJ, Van Roey P (2002). "Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate.". J. Biol. Chem. 277 (27): 24522–9. doi:10.1074/jbc.M202020200. PMID 11953431.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.". J. Proteome Res. 2 (1): 69–79. PMID 12643545.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
He P, Varticovski L, Bowman ED, et al. (2004). "Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray.". Hum. Pathol. 35 (10): 1196–209. PMID 15492986.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Eisele LE, Chave KJ, Lehning AC, Ryan TJ (2006). "Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer.". Biochim. Biophys. Acta 1764 (9): 1479–86. doi:10.1016/j.bbapap.2006.06.008. PMID 16945597.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
Hayashi H, Fujimaki C, Inoue K, et al. (2007). "Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population.". Biol. Pharm. Bull. 30 (4): 839–41. PMID 17409534.