FUT5

From Wikipedia, the free encyclopedia

Fucosyltransferase 5 (alpha (1,3) fucosyltransferase)

Identifiers

FUT5; FUC-TV

External IDs

Gene ontology
Molecular Function:	• transferase activity, transferring glycosyl groups • 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity • alpha(1,3)-fucosyltransferase activity
Cellular Component:	• Golgi apparatus • membrane • integral to membrane
Biological Process:	• carbohydrate metabolic process • protein amino acid glycosylation • L-fucose catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_002034 (mRNA)
NP_002025 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 19: 5.82 - 5.82 Mb

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Pubmed search

[1]

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Fucosyltransferase 5 (alpha (1,3) fucosyltransferase), also known as FUT5, is a human gene.^[1]

[edit] References

^ Entrez Gene: FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase).

[edit] Further reading

Chiu PC, Chung MK, Koistinen R, et al. (2007). "Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding.". J. Cell. Sci. 120 (Pt 1): 33–44. doi:10.1242/jcs.03258. PMID 17148576.
Inaba Y, Ohyama C, Kato T, et al. (2004). "Gene transfer of alpha1,3-fucosyltransferase increases tumor growth of the PC-3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells.". Int. J. Cancer 107 (6): 949–57. doi:10.1002/ijc.11513. PMID 14601054.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.". J. Biol. Chem. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
Nishihara S, Iwasaki H, Kaneko M, et al. (2000). "Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue.". FEBS Lett. 462 (3): 289–94. PMID 10622713.
McCurley RS, Recinos A, Olsen AS, et al. (1995). "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21.". Genomics 26 (1): 142–6. PMID 7782074.
Cameron HS, Szczepaniak D, Weston BW (1995). "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.". J. Biol. Chem. 270 (34): 20112–22. PMID 7650030.
Weston BW, Nair RP, Larsen RD, Lowe JB (1992). "Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities.". J. Biol. Chem. 267 (6): 4152–60. PMID 1740457.
Weston BW, Smith PL, Kelly RJ, Lowe JB (1992). "Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.". J. Biol. Chem. 267 (34): 24575–84. PMID 1339443.