FAU (gene)

From Wikipedia, the free encyclopedia

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30

Identifiers

FAU; FAU1; FLJ22986; RPS30

External IDs

OMIM: 134690 MGI: 102547 HomoloGene: 37562

Gene ontology
Molecular Function:	• molecular_function • RNA binding • structural constituent of ribosome
Cellular Component:	• cellular_component • intracellular • cytoplasm • ribosome • cytosolic small ribosomal subunit (sensu Eukaryota)
Biological Process:	• translation • protein modification process • biological_process

Orthologs

Human

Mouse

Refseq

NM_001997 (mRNA)
NP_001988 (protein)

NM_007990 (mRNA)
NP_032016 (protein)

Location

Chr 11: 64.64 - 64.65 Mb

Chr 19: 6.06 - 6.06 Mb

Pubmed search

[1]

[2]

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30, also known as FAU, is a human gene.^[1]

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin.^[1]

[edit] References

^ ^a ^b Entrez Gene: FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30.

[edit] Further reading

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. PMID 8722009.
Kas K, Michiels L, Merregaert J (1992). "Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein.". Biochem. Biophys. Res. Commun. 187 (2): 927–33. PMID 1326960.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. PMID 7821789.
Michiels L, Van der Rauwelaert E, Van Hasselt F, et al. (1993). "fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus.". Oncogene 8 (9): 2537–46. PMID 8395683.
Kas K, Schoenmakers E, van de Ven W, et al. (1993). "Assignment of the human FAU gene to a subregion of chromosome 11q13.". Genomics 17 (2): 387–92. doi:10.1006/geno.1993.1337. PMID 8406491.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144–9. PMID 8706699.
Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes.". Genome Res. 8 (5): 509–23. PMID 9582194.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Rossman TG, Visalli MA, Komissarova EV (2003). "fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence.". Oncogene 22 (12): 1817–21. doi:10.1038/sj.onc.1206283. PMID 12660817.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Mourtada-Maarabouni M, Kirkham L, Farzaneh F, Williams GT (2005). "Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression.". Oncogene 23 (58): 9419–26. doi:10.1038/sj.onc.1208048. PMID 15543234.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMID 15883184.