FAP (gene)

From Wikipedia, the free encyclopedia

Fibroblast activation protein, alpha

PDB rendering based on 1z68.

Available structures: 1z68

Identifiers

Symbol(s)

FAP; DPPIV; DKFZp686G13158; FAPA; SEPRASE

External IDs

OMIM: 600403 MGI: 109608 HomoloGene: 48282

Gene ontology
Molecular Function:	• metalloendopeptidase activity • dipeptidyl-peptidase IV activity • prolyl oligopeptidase activity • protein homodimerization activity
Cellular Component:	• membrane • integral to membrane • lamellipodium
Biological Process:	• proteolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004460 (mRNA)
NP_004451 (protein)

NM_007986 (mRNA)
NP_032012 (protein)

Location

Chr 2: 162.74 - 162.81 Mb

Chr 2: 62.3 - 62.37 Mb

Pubmed search

[1]

[2]

Fibroblast activation protein, alpha, also known as FAP, is a human gene.^[1]

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: FAP fibroblast activation protein, alpha.

[edit] Further reading

Rettig WJ, Su SL, Fortunato SR, et al. (1994). "Fibroblast activation protein: purification, epitope mapping and induction by growth factors.". Int. J. Cancer 58 (3): 385–92. PMID 7519584.
Mathew S, Scanlan MJ, Mohan Raj BK, et al. (1995). "The gene for fibroblast activation protein alpha (FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23.". Genomics 25 (1): 335–7. PMID 7774951.
Scanlan MJ, Raj BK, Calvo B, et al. (1994). "Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.". Proc. Natl. Acad. Sci. U.S.A. 91 (12): 5657–61. PMID 7911242.
Piñeiro-Sánchez ML, Goldstein LA, Dodt J, et al. (1997). "Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease.". J. Biol. Chem. 272 (12): 7595–601. PMID 9065413.
Goldstein LA, Ghersi G, Piñeiro-Sánchez ML, et al. (1997). "Molecular cloning of seprase: a serine integral membrane protease from human melanoma.". Biochim. Biophys. Acta 1361 (1): 11–9. PMID 9247085.
Goldstein LA, Chen WT (2000). "Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform.". J. Biol. Chem. 275 (4): 2554–9. PMID 10644713.
Ghersi G, Dong H, Goldstein LA, et al. (2002). "Regulation of fibroblast migration on collagenous matrix by a cell surface peptidase complex.". J. Biol. Chem. 277 (32): 29231–41. doi:10.1074/jbc.M202770200. PMID 12023964.
Levy MT, McCaughan GW, Marinos G, Gorrell MD (2002). "Intrahepatic expression of the hepatic stellate cell marker fibroblast activation protein correlates with the degree of fibrosis in hepatitis C virus infection.". Liver 22 (2): 93–101. PMID 12028401.
Artym VV, Kindzelskii AL, Chen WT, Petty HR (2002). "Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton.". Carcinogenesis 23 (10): 1593–601. PMID 12376466.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gorrell MD, Wang XM, Levy MT, et al. (2003). "Intrahepatic expression of collagen and fibroblast activation protein (FAP) in hepatitis C virus infection.". Adv. Exp. Med. Biol. 524: 235–43. PMID 12675244.
Jin X, Iwasa S, Okada K, et al. (2003). "Expression patterns of seprase, a membrane serine protease, in cervical carcinoma and cervical intraepithelial neoplasm.". Anticancer Res. 23 (4): 3195–8. PMID 12926053.
Iwasa S, Jin X, Okada K, et al. (2003). "Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer.". Cancer Lett. 199 (1): 91–8. PMID 12963128.
Goodman JD, Rozypal TL, Kelly T (2003). "Seprase, a membrane-bound protease, alleviates the serum growth requirement of human breast cancer cells.". Clin. Exp. Metastasis 20 (5): 459–70. PMID 14524536.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Okada K, Chen WT, Iwasa S, et al. (2004). "Seprase, a membrane-type serine protease, has different expression patterns in intestinal- and diffuse-type gastric cancer.". Oncology 65 (4): 363–70. doi:10.1159/000074650. PMID 14707457.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Cheng JD, Valianou M, Canutescu AA, et al. (2005). "Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth.". Mol. Cancer Ther. 4 (3): 351–60. doi:10.1158/1535-7163.MCT-04-0269. PMID 15767544.
Aertgeerts K, Levin I, Shi L, et al. (2005). "Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha.". J. Biol. Chem. 280 (20): 19441–4. doi:10.1074/jbc.C500092200. PMID 15809306.
Fassnacht M, Lee J, Milazzo C, et al. (2006). "Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy.". Clin. Cancer Res. 11 (15): 5566–71. doi:10.1158/1078-0432.CCR-05-0699. PMID 16061874.