FABP3

From Wikipedia, the free encyclopedia

Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)

PDB rendering based on 1g5w.

Available structures: 1g5w, 1hmr, 1hms, 1hmt, 2hmb

Identifiers

Symbol(s)

FABP3; FABP11; H-FABP; MDGI; O-FABP

External IDs

OMIM: 134651 MGI: 95476 HomoloGene: 68379

Gene ontology
Molecular Function:	• lipid transporter activity • fatty acid binding
Cellular Component:	• soluble fraction • cytoplasm
Biological Process:	• transport • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004102 (mRNA)
NP_004093 (protein)

NM_010174 (mRNA)
NP_034304 (protein)

Location

Chr 1: 31.61 - 31.62 Mb

Chr 4: 129.81 - 129.82 Mb

Pubmed search

[1]

[2]

Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor), also known as FABP3, is a human gene.^[1]

The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer.^[1]

[edit] References

^ ^a ^b Entrez Gene: FABP3 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor).

[edit] Further reading

Spener F, Unterberg C, Börchers T, Grosse R (1991). "Characteristics of fatty acid-binding proteins and their relation to mammary-derived growth inhibitor.". Mol. Cell. Biochem. 98 (1-2): 57–68. PMID 2266970.
Zanotti G, Scapin G, Spadon P, et al. (1992). "Three-dimensional structure of recombinant human muscle fatty acid-binding protein.". J. Biol. Chem. 267 (26): 18541–50. PMID 1526991.
Peeters RA, Veerkamp JH, Geurts van Kessel A, et al. (1991). "Cloning of the cDNA encoding human skeletal-muscle fatty-acid-binding protein, its peptide sequence and chromosomal localization.". Biochem. J. 276 ( Pt 1): 203–7. PMID 1710107.
Tanaka T, Hirota Y, Sohmiya K, et al. (1991). "Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction.". Clin. Biochem. 24 (2): 195–201. PMID 2040092.
Börchers T, Højrup P, Nielsen SU, et al. (1991). "Revision of the amino acid sequence of human heart fatty acid-binding protein.". Mol. Cell. Biochem. 98 (1-2): 127–33. PMID 2266954.
Offner GD, Brecher P, Sawlivich WB, et al. (1988). "Characterization and amino acid sequence of a fatty acid-binding protein from human heart.". Biochem. J. 252 (1): 191–8. PMID 3421901.
Kovalyov LI, Shishkin SS, Efimochkin AS, et al. (1996). "The major protein expression profile and two-dimensional protein database of human heart.". Electrophoresis 16 (7): 1160–9. PMID 7498159.
Nielsen SU, Spener F (1993). "Fatty acid-binding protein from rat heart is phosphorylated on Tyr19 in response to insulin stimulation.". J. Lipid Res. 34 (8): 1355–66. PMID 7691977.
Huynh HT, Larsson C, Narod S, Pollak M (1995). "Tumor suppressor activity of the gene encoding mammary-derived growth inhibitor.". Cancer Res. 55 (11): 2225–31. PMID 7757968.
Young AC, Scapin G, Kromminga A, et al. (1994). "Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids.". Structure 2 (6): 523–34. PMID 7922029.
Yang Y, Spitzer E, Kenney N, et al. (1994). "Members of the fatty acid binding protein family are differentiation factors for the mammary gland.". J. Cell Biol. 127 (4): 1097–109. PMID 7962070.
Troxler RF, Offner GD, Jiang JW, et al. (1994). "Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33.". Hum. Genet. 92 (6): 563–6. PMID 8262516.
Watanabe K, Wakabayashi H, Veerkamp JH, et al. (1993). "Immunohistochemical distribution of heart-type fatty acid-binding protein immunoreactivity in normal human tissues and in acute myocardial infarct.". J. Pathol. 170 (1): 59–65. doi:10.1002/path.1711700110. PMID 8326460.
Phelan CM, Larsson C, Baird S, et al. (1996). "The human mammary-derived growth inhibitor (MDGI) gene: genomic structure and mutation analysis in human breast tumors.". Genomics 34 (1): 63–8. doi:10.1006/geno.1996.0241. PMID 8661024.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhao Y, Meng XM, Wei YJ, et al. (2004). "Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I.". J. Mol. Med. 81 (5): 297–304. doi:10.1007/s00109-003-0427-x. PMID 12721663.
Cheon MS, Kim SH, Fountoulakis M, Lubec G (2004). "Heart type fatty acid binding protein (H-FABP) is decreased in brains of patients with Down syndrome and Alzheimer's disease.". J. Neural Transm. Suppl. (67): 225–34. PMID 15068254.
Hashimoto T, Kusakabe T, Sugino T, et al. (2005). "Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis.". Pathobiology 71 (5): 267–73. doi:10.1159/000080061. PMID 15459486.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.