EPHA3

From Wikipedia, the free encyclopedia

EPH receptor A3

PDB rendering based on 2gsf.

Available structures: 2gsf

Identifiers

Symbol(s)

EPHA3; ETK; ETK1; HEK; HEK4; TYRO4

External IDs

OMIM: 179611 MGI: 99612 HomoloGene: 21083

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • receptor activity • ephrin receptor activity • ATP binding • transferase activity
Cellular Component:	• integral to plasma membrane • membrane • integral to membrane
Biological Process:	• protein amino acid phosphorylation • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005233 (mRNA)
NP_005224 (protein)

NM_010140 (mRNA)
NP_034270 (protein)

Location

Chr 3: 89.24 - 89.61 Mb

Chr 16: 63.49 - 63.81 Mb

Pubmed search

[1]

[2]

EPH receptor A3, also known as EPHA3, is a human gene.^[1]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: EPHA3 EPH receptor A3.

[edit] Further reading

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
Ernst AF, Jurney WM, McLoon SC (1999). "Mechanisms involved in development of retinotectal connections: roles of Eph receptor tyrosine kinases, NMDA receptors and nitric oxide.". Prog. Brain Res. 118: 115–31. PMID 9932438.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
Wicks IP, Wilkinson D, Salvaris E, Boyd AW (1992). "Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines.". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1611–5. PMID 1311845.
Boyd AW, Ward LD, Wicks IP, et al. (1992). "Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line.". J. Biol. Chem. 267 (5): 3262–7. PMID 1737782.
Beckmann MP, Cerretti DP, Baum P, et al. (1994). "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.". EMBO J. 13 (16): 3757–62. PMID 8070404.
Wicks IP, Lapsys NM, Baker E, et al. (1994). "Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11.2.". Genomics 19 (1): 38–41. doi:10.1006/geno.1994.1009. PMID 8188238.
Cerretti DP, Vanden Bos T, Nelson N, et al. (1996). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases.". Mol. Immunol. 32 (16): 1197–205. PMID 8559144.
Lackmann M, Mann RJ, Kravets L, et al. (1997). "Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor.". J. Biol. Chem. 272 (26): 16521–30. PMID 9195962.
Kozlosky CJ, VandenBos T, Park L, et al. (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain.". Cytokine 9 (8): 540–9. doi:10.1006/cyto.1997.0199. PMID 9245480.
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403–4. PMID 9267020.
Lackmann M, Oates AC, Dottori M, et al. (1998). "Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization.". J. Biol. Chem. 273 (32): 20228–37. PMID 9685371.
Ciossek T, Monschau B, Kremoser C, et al. (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro.". Eur. J. Neurosci. 10 (5): 1574–80. PMID 9751130.