ENTPD3

From Wikipedia, the free encyclopedia

Ectonucleoside triphosphate diphosphohydrolase 3

Identifiers

ENTPD3; CD39L3; HB6; NTPDase-3

External IDs

OMIM: 603161 MGI: 1321386 HomoloGene: 68171

Gene ontology
Molecular Function:	• magnesium ion binding • calcium ion binding • hydrolase activity • nucleoside-diphosphatase activity • nucleoside-triphosphatase activity
Cellular Component:	• plasma membrane • integral to membrane
Biological Process:	• nucleoside diphosphate catabolic process • nucleoside triphosphate catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001248 (mRNA)
NP_001239 (protein)

NM_178676 (mRNA)
NP_848791 (protein)

Location

Chr 3: 40.4 - 40.45 Mb

Chr 9: 120.39 - 120.42 Mb

Pubmed search

[1]

[2]

Ectonucleoside triphosphate diphosphohydrolase 3, also known as ENTPD3, is a human gene.^[1]

ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases.^[1]

[edit] References

^ ^a ^b Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3.

[edit] Further reading

Munkonda MN, Kauffenstein G, Kukulski F, et al. (2007). "Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists.". Biochem. Pharmacol. 74 (10): 1524-34. doi:10.1016/j.bcp.2007.07.033. PMID 17727821.
Ivanenkov VV, Meller J, Kirley TL (2005). "Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling.". Biochemistry 44 (25): 8998-9012. doi:10.1021/bi047487z. PMID 15966724.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yang F, Hicks-Berger CA, Smith TM, Kirley TL (2001). "Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions.". Biochemistry 40 (13): 3943-50. PMID 11300774.
Smith TM, Lewis Carl SA, Kirley TL (1999). "Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase.". Biochemistry 38 (18): 5849-57. doi:10.1021/bi990171k. PMID 10231536.
Chadwick BP, Frischauf AM (1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.". Genomics 50 (3): 357-67. doi:10.1006/geno.1998.5317. PMID 9676430.
Smith TM, Kirley TL (1998). "Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1.". Biochim. Biophys. Acta 1386 (1): 65-78. PMID 9675246.
Chadwick BP, Frischauf AM (1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes.". Mamm. Genome 8 (9): 668-72. PMID 9271669.