DNAJA3

From Wikipedia, the free encyclopedia

DnaJ (Hsp40) homolog, subfamily A, member 3

PDB rendering based on 2ctt.

Available structures: 2ctt, 2dn9

Identifiers

Symbol(s)

DNAJA3; FLJ45758; TID1; hTid-1

External IDs

OMIM: 608382 MGI: 1933786 HomoloGene: 36170

Gene ontology
Molecular Function:	• small GTPase regulator activity • zinc ion binding • heat shock protein binding • metal ion binding • unfolded protein binding
Cellular Component:	• nucleus • mitochondrion • mitochondrial matrix • cytosol
Biological Process:	• protein folding • small GTPase mediated signal transduction • regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005147 (mRNA)
NP_005138 (protein)

NM_023646 (mRNA)
NP_076135 (protein)

Location

Chr 16: 4.42 - 4.45 Mb

Chr 16: 4.6 - 4.62 Mb

Pubmed search

[1]

[2]

DnaJ (Hsp40) homolog, subfamily A, member 3, also known as DNAJA3, is a human gene.

DNAJA3 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins. For background information on the DNAJ family, see MIM 608375.[supplied by OMIM]^[1]

[edit] References

^ Entrez Gene: DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Schilling B, De-Medina T, Syken J, et al. (1998). "A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein.". Virology 247 (1): 74–85. doi:10.1006/viro.1998.9220. PMID 9683573.
Syken J, De-Medina T, Münger K (1999). "TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions.". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8499–504. PMID 10411904.
Shinohara M, Gasior SL, Bishop DK, Shinohara A (2000). "Tid1/Rdh54 promotes colocalization of rad51 and dmc1 during meiotic recombination.". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10814–9. PMID 11005857.
Trentin GA, Yin X, Tahir S, et al. (2001). "A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein.". J. Biol. Chem. 276 (16): 13087–95. doi:10.1074/jbc.M009267200. PMID 11116152.
Ohtsuka K, Hata M (2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature.". Cell Stress Chaperones 5 (2): 98–112. PMID 11147971.
Sarkar S, Pollack BP, Lin KT, et al. (2002). "hTid-1, a human DnaJ protein, modulates the interferon signaling pathway.". J. Biol. Chem. 276 (52): 49034–42. doi:10.1074/jbc.M103683200. PMID 11679576.
Yin X, Rozakis-Adcock M (2002). "Genomic organization and expression of the human tumorous imaginal disc (TID1) gene.". Gene 278 (1-2): 201–10. PMID 11707338.
Cheng H, Cenciarelli C, Shao Z, et al. (2002). "Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70.". Curr. Biol. 11 (22): 1771–5. PMID 11719219.
Cheng H, Cenciarelli C, Tao M, et al. (2002). "HTLV-1 Tax-associated hTid-1, a human DnaJ protein, is a repressor of Ikappa B kinase beta subunit.". J. Biol. Chem. 277 (23): 20605–10. doi:10.1074/jbc.M201204200. PMID 11927590.
Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.". J. Immunol. 169 (2): 1102–9. PMID 12097419.
Sasaki S, Nakamura T, Arakawa H, et al. (2002). "Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer.". Oncogene 21 (32): 5024–30. doi:10.1038/sj.onc.1205627. PMID 12118383.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Syken J, Macian F, Agarwal S, et al. (2003). "TID1, a mammalian homologue of the drosophila tumor suppressor lethal(2) tumorous imaginal discs, regulates activation-induced cell death in Th2 cells.". Oncogene 22 (30): 4636–41. doi:10.1038/sj.onc.1206569. PMID 12879007.
Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lo JF, Hayashi M, Woo-Kim S, et al. (2004). "Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival.". Mol. Cell. Biol. 24 (6): 2226–36. PMID 14993262.
Edwards KM, Münger K (2004). "Depletion of physiological levels of the human TID1 protein renders cancer cell lines resistant to apoptosis mediated by multiple exogenous stimuli.". Oncogene 23 (52): 8419–31. doi:10.1038/sj.onc.1207732. PMID 15156195.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.