Cohesin
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| Cohesin | |
|---|---|
 Cohesin. Cohesin, binds sister chromatids together during metaphase (PDB: 1w1w). |
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| Genetic data | |
| Gene code: | [1] ID#: GI:2570096 |
| Protein Structure/Function | |
| Structure: | [2]1W1W |
Cohesin is the protein responsible for binding the sister chromatids during mitosis through the G2 phase and into mitosis phase. At metaphase, most cohesin is removed, except for some at the centromere. At Anaphase, securin, an inhibitory subunit of separase, is hydrolyzed. Separase hydrolyzes the remaining cohesin.
[edit] See also
[edit] External links
- Michaelis C, Ciosk R, Nasmyth K (1997). "Cohesins: chromosomal proteins that prevent premature separation of sister chromatids". Cell 91 (1): 35–45. PMID 9335333.
- Guacci V, Koshland D, Strunnikov A (1997). "A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae". Cell 91 (1): 47–57. PMID 9335334.
- Tóth A, Ciosk R, Uhlmann F, Galova M, Schleiffer A, Nasmyth K (1999). "Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication". Genes Dev. 13 (3): 320–33. PMID 9990856.
- Uhlmann F, Lottspeich F, Nasmyth K (1999). "Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1". Nature 400 (6739): 37–42. doi:. PMID 10403247.
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