Class II PI 3-kinases

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Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.

Class II PI 3-kinases were the most recently identified class of PI 3-kinases and little is currently known about these enzymes.

There are three class II PI 3-kinase isoforms expressed in mammalian cells;

• PI3K-C2α
• PI3K-C2β
• PI3K-C2γ

[edit] See also

phosphoinositide 3-kinase

[edit] References

• Stein RC( 2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment Endocr Relat Cancer 8:237-248 [1]

• Foster FM, Traer CJ, Abraham SM, and Fry MJ (2003) The phosphoinositide (PI) 3-kinase family J Cell Sci 116:3037-3040.[2]

• Vanhaesebroeck B, Waterfield MD.(1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 253(1):239-54.[3]

v • d • e Transferases: Phosphotransferases/kinases (EC 2.7) 2.7.1 - OH acceptor Hexo- - Gluco- - Fructo- (Hepatic fructo-) - Galacto- - Phosphofructo- (1, 2) - Riboflavin - Shikimate - Thymidine - NAD+ - Glycerol - Pantothenate - Mevalonate - Pyruvate - Deoxycytidine - PFP - Diacylglycerol - Bruton's tyrosine - Phosphoinositide 3 (Class I PI 3, Class II PI 3) - Sphingosine 2.7.2 - COOH acceptor Phosphoglycerate - Aspartate 2.7.3 - N acceptor Creatine 2.7.4 - PO4 acceptor Phosphomevalonate - Adenylate - Nucleoside-diphosphate 2.7.6 - P2O7 Ribose-phosphate diphosphokinase - Thiamine pyrophosphokinase 2.7.7 - nucleotidyl- Integrase - PNPase - Polymerase - RNase PH - UDP-glucose pyrophosphorylase - Galactose-1-phosphate uridylyltransferase -Terminal deoxynucleotidyl transferase - RNA replicase - Reverse transcriptase (Telomerase) - Transposase 2.7.8 - other phos. N-acetylglucosamine-1-phosphate transferase 2.7.10-11 - protein Tyrosine - Serine/threonine-specific