CISH

From Wikipedia, the free encyclopedia

Cytokine inducible SH2-containing protein

Identifiers

CISH; CIS; CIS-1; G18; SOCS

External IDs

OMIM: 602441 MGI: 103159 HomoloGene: 7667

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• cellular_component
Biological Process:	• regulation of cell growth • intracellular signaling cascade • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_145071 (mRNA)
NP_659508 (protein)

NM_009895 (mRNA)
NP_034025 (protein)

Location

Chr 3: 50.62 - 50.62 Mb

Chr 9: 107.14 - 107.16 Mb

Pubmed search

[1]

[2]

Cytokine inducible SH2-containing protein, also known as CISH, is a human gene.^[1]

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor.^[1]

[edit] References

^ ^a ^b Entrez Gene: CISH cytokine inducible SH2-containing protein.

[edit] Further reading

Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. PMID 12076535.
Yoshimura A, Ohkubo T, Kiguchi T, et al. (1995). "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.". EMBO J. 14 (12): 2816–26. PMID 7796808.
Uchida K, Yoshimura A, Inazawa J, et al. (1998). "Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues.". Cytogenet. Cell Genet. 78 (3-4): 209–12. PMID 9465889.
Verdier F, Chrétien S, Muller O, et al. (1998). "Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein.". J. Biol. Chem. 273 (43): 28185–90. PMID 9774439.
Aman MJ, Migone TS, Sasaki A, et al. (1999). "CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling.". J. Biol. Chem. 274 (42): 30266–72. PMID 10514520.
Okabe S, Tauchi T, Morita H, et al. (1999). "Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway.". Exp. Hematol. 27 (10): 1542–7. PMID 10517496.
Jiang C, Yu L, Zhao Y, et al. (2000). "Cloning and characterization of CIS 1b (cytokine inducible SH2-containing protein 1b), an alternative splicing form of CIS 1 gene.". DNA Seq. 11 (1-2): 149–54. PMID 10902923.
Dogusan Z, Hooghe-Peters EL, Berus D, et al. (2000). "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines.". J. Neuroimmunol. 109 (1): 34–9. PMID 10969179.
Yousefi S, Cooper PR, Mueck B, et al. (2000). "cDNA representational difference analysis of human neutrophils stimulated by GM-CSF.". Biochem. Biophys. Res. Commun. 277 (2): 401–9. doi:10.1006/bbrc.2000.3678. PMID 11032736.
Dif F, Saunier E, Demeneix B, et al. (2001). "Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor.". Endocrinology 142 (12): 5286–93. PMID 11713228.
Federici M, Giustizieri ML, Scarponi C, et al. (2002). "Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1.". J. Immunol. 169 (1): 434–42. PMID 12077274.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Du L, Frick GP, Tai LR, et al. (2003). "Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytes.". Endocrinology 144 (3): 868–76. PMID 12586763.
Chen S, Anderson PO, Li L, et al. (2003). "Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells.". Int. Immunol. 15 (3): 403–9. PMID 12618484.
Yamasaki K, Hanakawa Y, Tokumaru S, et al. (2003). "Suppressor of cytokine signaling 1/JAB and suppressor of cytokine signaling 3/cytokine-inducible SH2 containing protein 3 negatively regulate the signal transducers and activators of transcription signaling pathway in normal human epidermal keratinocytes.". J. Invest. Dermatol. 120 (4): 571–80. doi:10.1046/j.1523-1747.2003.12100.x. PMID 12648219.
Cheng J, Zhang D, Zhou C, Marasco WA (2004). "Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells.". Leuk. Res. 28 (1): 71–82. PMID 14630083.
Bayle J, Letard S, Frank R, et al. (2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.". J. Biol. Chem. 279 (13): 12249–59. doi:10.1074/jbc.M313381200. PMID 14707129.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Hunter MG, Jacob A, O'donnell LC, et al. (2004). "Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia/acute myelogenous leukemia.". J. Immunol. 173 (8): 5036–45. PMID 15470047.