CHST4

From Wikipedia, the free encyclopedia

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

Identifiers

External IDs

Gene ontology
Molecular Function:	• N-acetylglucosamine 6-O-sulfotransferase activity • transferase activity
Cellular Component:	• trans-Golgi network • membrane • integral to membrane • intrinsic to Golgi membrane
Biological Process:	• carbohydrate metabolic process • N-acetylglucosamine metabolic process • protein amino acid sulfation • sulfur metabolic process • cell motility • inflammatory response • immune response • cell adhesion • cell-cell signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005769 (mRNA)
NP_005760 (protein)

NM_011998 (mRNA)
NP_036128 (protein)

Location

Chr 16: 70.12 - 70.13 Mb

Chr 8: 112.92 - 112.93 Mb

Pubmed search

[1]

[2]

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4, also known as CHST4, is a human gene.^[1]

[edit] References

^ Entrez Gene: CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4.

[edit] Further reading

Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein.". J. Virol. 66 (12): 6953–9. PMID 1433500.
Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.". J. Virol. 67 (2): 943–52. PMID 8419650.
Bistrup A, Bhakta S, Lee JK, et al. (1999). "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin.". J. Cell Biol. 145 (4): 899–910. PMID 10330415.
Hemmerich S, Lee JK, Bhakta S, et al. (2001). "Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family.". Glycobiology 11 (1): 75–87. PMID 11181564.
Li X, Tu L, Murphy PG, et al. (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin.". J. Leukoc. Biol. 69 (4): 565–74. PMID 11310842.
Yeh JC, Hiraoka N, Petryniak B, et al. (2001). "Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase.". Cell 105 (7): 957–69. PMID 11439191.
Uchimura K, El-Fasakhany FM, Hori M, et al. (2002). "Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression.". J. Biol. Chem. 277 (6): 3979–84. doi:10.1074/jbc.M106587200. PMID 11726653.
Seko A, Nagata K, Yonezawa S, Yamashita K (2003). "Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma.". Glycobiology 12 (6): 379–88. PMID 12107080.
Akama TO, Misra AK, Hindsgaul O, Fukuda MN (2003). "Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate.". J. Biol. Chem. 277 (45): 42505–13. doi:10.1074/jbc.M207412200. PMID 12218059.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
de Graffenried CL, Bertozzi CR (2003). "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis.". J. Biol. Chem. 278 (41): 40282–95. doi:10.1074/jbc.M304928200. PMID 12855678.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
de Graffenried CL, Bertozzi CR (2004). "The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity.". J. Biol. Chem. 279 (38): 40035–43. doi:10.1074/jbc.M405709200. PMID 15220337.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Timson G, Banavali S, Gutierrez MI, et al. (2006). "High level expression of N-acetylgluosamine-6-O-sulfotransferase is characteristic of a subgroup of paediatric precursor-B acute lymphoblastic leukaemia.". Cancer Lett. 242 (2): 239–44. doi:10.1016/j.canlet.2005.11.012. PMID 16386360.