Chitin synthase

From Wikipedia, the free encyclopedia

In enzymology, a chitin synthase (EC 2.4.1.16) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n⁺1

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and [[[1,4-(N-acetyl-beta-D-glucosaminyl)]n]], whereas its two products are UDP and [[[1,4-(N-acetyl-beta-D-glucosaminyl)]n+1]].

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase. Other names in common use include chitin-UDP N-acetylglucosaminyltransferase, chitin-uridine diphosphate acetylglucosaminyltransferase, chitin synthetase, and trans-N-acetylglucosaminosylase. This enzyme participates in aminosugars metabolism.

[edit] References

• IUBMB entry for 2.4.1.16
• BRENDA references for 2.4.1.16 (Recommended.)
• PubMed references for 2.4.1.16
• PubMed Central references for 2.4.1.16
• Google Scholar references for 2.4.1.16
• GLASER L, BROWN DH (1957). "The synthesis of chitin in cell-free extracts of Neurospora crassa". J. Biol. Chem. 228: 729–42. PMID 13475355. 
• Sburlati A, Cabib E (1986). "Chitin synthetase 2, a presumptive participant in septum formation in Saccharomyces cerevisiae". J. Biol. Chem. 261: 15147–52. PMID 2945823. 

[edit] External links

The CAS registry number for this enzyme class is 9030-18-6.

• IUBMB entry for 2.4.1.16

• KEGG entry for 2.4.1.16

• BRENDA entry for 2.4.1.16

• NiceZyme view of 2.4.1.16

• EC2PDB: PDB structures for 2.4.1.16

• PRIAM entry for 2.4.1.16

• PUMA2 entry for 2.4.1.16

• IntEnz: Integrated Enzyme entry for 2.4.1.16

• MetaCyc entry for 2.4.1.16

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004100: chitin synthase

• AMIGO entry for GO code 0004100: chitin synthase