Talk:Centriole
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Article Grading: The following comments were left by the quality and importance raters: (edit · history · refresh · how to use this template) Rated "high" as high school/SAT biology content. The article needs expansion, references and pictures. - tameeria 23:29, 18 February 2007 (UTC) |
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[edit] Quote
In 1996 Dr Stuart Black and associates at the University of Chester discovered in a longitudinal study that children suffering stunted growth suffered from greatly reduced rates of cell mitosis, this also affected their ability to kill as quickly when compared to a control sample of those of average height. This is believed to be significant in showing that their centrioles had greater difficulty initiating the mitosis process due to the third spindle only consisting of two microtubules, instead of three.
I deleted this from the main article. There's no reference to the study in the article and i couldn't find itin a quick pub med search. It's also not written well- what, the shorter children couldn't kill as quicly as their taller counterparts? I doubt that. Amutepiggy 23:08, 9 November 2006 (UTC)
So what is the evidence that centrioles actually have anything to do with this? I dont think there is any evidence by the sounds of it... And what is the third spindle?!
Centrioles are structurally identical to the basal body
I thought it was the centrosome that the basal body was identical to, not the centrioles. I'm not certain enough to change it though. Anyone know? 80.42.108.167 10:40, 9 April 2006 (UTC)
Unless you go into more detail about the processes (including the biogenesis of cilia and flagellum)that form the basal body and spindle apparatus, I'd leave it as it is for now. In eukaryotes, most authors refer to the basal body as being similar(homologous)to the centriole. The centrosome refers to the central microtubule organizing center (MTOC) that the nine double or triplet microtubules grow out of to make up the centriole. In cilia and flagellum there are then two more microtubules in the middle of the centriole that form the basal body that the cilia or flagellum grow out of. The centriole forms the spindle for mitosis or the basal body for cilia and flagellum, but not all basal bodies are the same and they undergo a flagellar modification in different species, e.g., the flagellar hook-basal body complex with the protein FliE. Also, dyneins then move back down the centrosome microtubules to transport ATP toward the centrosome (MTOC).
In Dr. Jim Deacon, of the University of Edinburgh, Genetic's Glossary: "The centriole is a short cylindrical organelle, found in pairs arranged at right angles to each other at the centre of a microtubule organizing centre (MTOC) or centrosome, found in eukaryotes (except in higher plants). A centriole is similar in structure to the basal body found at the base of eukaryotic cilia and flagella and organises the axoneme, the bundle of microtubules and other proteins forming the core of each cilium or flagellum. The centrosome organizes formation of a spindle during mitosis or meiosis." http://helios.bto.ed.ac.uk/bto/glossary/c.htm
"[During the G1 and S phase of mitosis in mammalian cells] An older centriole differs functionally from a younger centriole by being able to assemble a primary cilium. This suggests a role for one or more of these proteins and for maturation in promoting the assembly of the cilium. Of those, only -tubulin has been identified to date in Chlamydomonas. In addition to the presence of the above proteins, the level of polyglutamylation on - and ß-tubulin is increased on older centrioles and on older basal bodies. Unlike centrioles, daughter basal bodies must mature early in their first cell cycle in order to assemble flagella or cilia and so for example, all basal bodies in the ciliated epithelium of the trachea have the ODF2 epitope (McKean et al., 2003). Therefore, there is a need for an additional maturation event in basal bodies which we refer to as early maturation and which must occur at M/G1 phase of the cell cycle rather than in G2/M phase, as for centrioles." From: "Mutations in -tubulin promote basal body maturation and flagellar assembly in the absence of -tubulin," by Sylvia Fromherz, Thomas H. Giddings, Jr, Natalia Gomez-Ospina1, and Susan K. Dutcher. Journal of Cell Science 117, 303-314 (2004). Published online at http://jcs.biologists.org/cgi/content/full/117/2/303
"In a confluent culture [of Chlamydomonas], Fa2p is observed lying on the presumptive ciliary SOFA and at the base of both centrioles, one of which is serving as the basal body. During mitosis, Fa2p is associated with the duplicated centrioles and then with the polar region of the mitotic spindle in the mouse cells, as it is in Chlamydomonas.” From: “Cilia and the cell cycle?” by Lynne M. Quarmby and Jeremy D.K. Parker, JCB, Volume 169, Number 5, 707-710. Published online at http://www.jcb.org/cgi/content/full/169/5/707
[edit] A pair of small *balls*?
Alright, since Feb 8, The Structure said "A pair of small balls..." and referenced a penis, but was very well masked.
This was recitified, at first by placing in its place an ambiguous description, but then, when I found the original, replaced it with that. It now reads "A pair of small cylindrical structures made of protein that lie next to each other in a T shape, but not touching. The centrioles are constructed of nine microtubule triplets."Saint yondo 12:47, 29 March 2007 (UTC)
[edit] Eeh?
when broken down with a laser in cells that do not have them
How can you break donw something that does not exist? In cells that don't have them? I assume by "them" you mean centrioles?Tourskin 22:17, 13 May 2007 (UTC)
[edit] Centrosome/Centriole confusion
I removed the statement that centrioles were necessary for cell division. To quote p 114 of Biology (Campbell & Reece) 7th ed: "Although centrioles may help organize microtubule assembly, they are not essential for [cell division]" Maybe the author meant centrOSOME, but if you look at the centroSOME article, you'll find that even this appears not necessary. Either way, the two articles were contradicting each other, and should be cited if I'm wrong.
[edit] Please clean up!!!
there is some disgusting crap that some jerk came in and wrote. This is very inapropiate.
like "centrioles suck dick fibers to separate cum during the orgasms anaphase."
please clean up!!!! —Preceding unsigned comment added by 68.114.63.51 (talk) 12:23, 27 September 2007 (UTC)
[edit] Micrometers
How many micrometers wide??? 71.225.47.199 (talk) 23:54, 3 January 2008 (UTC)
