CENPA

From Wikipedia, the free encyclopedia

Centromere protein A

Identifiers

External IDs

OMIM: 117139 MGI: 88375 HomoloGene: 1369

Gene ontology
Molecular Function:	• DNA binding • chromatin binding
Cellular Component:	• chromosome, pericentric region • nucleosome • nucleus • chromosome
Biological Process:	• nucleosome assembly • chromosome organization and biogenesis (sensu Eukaryota)

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001042426 (mRNA)
NP_001035891 (protein)

NM_007681 (mRNA)
NP_031707 (protein)

Location

n/a

Chr 5: 30.94 - 30.95 Mb

Pubmed search

[1]

[2]

Centromere protein A, also known as CENPA, is a human gene.^[1]

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: CENPA centromere protein A.

[edit] Further reading

Palmer DK, O'Day K, Trong HL, et al. (1991). "Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone.". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3734–8. PMID 2023923.
Sullivan KF, Hechenberger M, Masri K (1994). "Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere.". J. Cell Biol. 127 (3): 581–92. PMID 7962047.
Shelby RD, Vafa O, Sullivan KF (1997). "Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites.". J. Cell Biol. 136 (3): 501–13. PMID 9024683.
Valdivia MM, Figueroa J, Iglesias C, Ortíz M (1998). "A novel centromere monospecific serum to a human autoepitope on the histone H3-like protein CENP-A.". FEBS Lett. 422 (1): 5–9. PMID 9475158.
Fowler KJ, Newson AJ, MacDonald AC, et al. (1998). "Chromosomal localization of mouse Cenpa gene.". Cytogenet. Cell Genet. 79 (3-4): 298–301. PMID 9605877.
Muro Y, Azuma N, Onouchi H, et al. (2000). "Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3.". Clin. Exp. Immunol. 120 (1): 218–23. PMID 10759786.
Lomonte P, Sullivan KF, Everett RD (2001). "Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0.". J. Biol. Chem. 276 (8): 5829–35. doi:10.1074/jbc.M008547200. PMID 11053442.
Uren AG, Wong L, Pakusch M, et al. (2001). "Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.". Curr. Biol. 10 (21): 1319–28. PMID 11084331.
Zeitlin SG, Shelby RD, Sullivan KF (2002). "CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.". J. Cell Biol. 155 (7): 1147–57. doi:10.1083/jcb.200108125. PMID 11756469.
Ando S, Yang H, Nozaki N, et al. (2002). "CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells.". Mol. Cell. Biol. 22 (7): 2229–41. PMID 11884609.
Saxena A, Saffery R, Wong LH, et al. (2002). "Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated.". J. Biol. Chem. 277 (30): 26921–6. doi:10.1074/jbc.M200620200. PMID 12011073.
Figueroa J, Pendón C, Valdivia MM (2003). "Molecular cloning and sequence analysis of hamster CENP-A cDNA.". BMC Genomics 3 (1): 11. PMID 12019018.
Saxena A, Wong LH, Kalitsis P, et al. (2003). "Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc.". Hum. Mol. Genet. 11 (19): 2319–29. PMID 12217960.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tomonaga T, Matsushita K, Yamaguchi S, et al. (2003). "Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer.". Cancer Res. 63 (13): 3511–6. PMID 12839935.
Kunitoku N, Sasayama T, Marumoto T, et al. (2004). "CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function.". Dev. Cell 5 (6): 853–64. PMID 14667408.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. PMID 15009096.
Yasuda S, Oceguera-Yanez F, Kato T, et al. (2004). "Cdc42 and mDia3 regulate microtubule attachment to kinetochores.". Nature 428 (6984): 767–71. doi:10.1038/nature02452. PMID 15085137.
Black BE, Foltz DR, Chakravarthy S, et al. (2004). "Structural determinants for generating centromeric chromatin.". Nature 430 (6999): 578–82. doi:10.1038/nature02766. PMID 15282608.
Sullivan BA, Karpen GH (2004). "Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin.". Nat. Struct. Mol. Biol. 11 (11): 1076–83. doi:10.1038/nsmb845. PMID 15475964.

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v • d • e Genetics: chromosomes

General	Karyotype - Ploidy - Meiosis

Classification	Autosome - Sex chromosome

Evolution	Chromosomal inversion - Chromosomal translocation - Polyploidy - Paleopolyploidy

Structure	Chromatin (Euchromatin, Heterochromatin) Histone (H1, H2A, H2B, H3, H4) Centromere (A, B, C1, C2, E, F, H, I, J, K, M, N, O, P, Q, T] Nucleosome - Telomere - Chromatid